Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

Recruiting now

Conditions studied: Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis, Chronic Inflammation

In brief

This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.

Key facts

Study ID

NCT04232566

Run by

Mayo Clinic

People needed

60

Starts

2022-02-20

Expected to finish

2027-12-30

Last updated by the study team

2026-01-28

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Undergoing gastric bypass surgery
• Confirmed AUROC F=0 or F>2 liver fibrosis
• Age 30-70 years
• BMI greater than 40 kg/m2
• Negative pregnancy test (female only)
• Lab Values: Normal TSH

You may not qualify if…

• Autoimmune diseases
• Hepatitis B or C positive
• Heavy alcohol use
• Active smoking history
• Active cancer history
• History of asthma
• History of COPD
• Taking Plavix or Coumadin
• Blood donation within past 2 months
• Glucocorticoid Therapy
• Taking antihistamine on regular basis

Where it is running

• Mayo Clinic in Arizona — Scottsdale, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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