A Comparative Study Between PF-06410293 and Humira® in Combination With Methotrexate in Participants With Active Rheumatoid Arthritis

Completed · Phase 3

Conditions studied: Rheumatoid Arthritis

In brief

The study will assess the impact of pharmacokinetics (PK), safety and immunogenicity after switches between PF-06410293 and adalimumab and with continuous dosing with adalimumab in combination with methotrexate in subjects with moderately to severely active rheumatoid arthritis.

Key facts

Study ID

NCT04230213

Run by

Pfizer

People needed

455

Starts

2020-01-13

Expected to finish

2021-06-22

Last updated by the study team

2024-02-22

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of RA based on 2010 ACR/EULAR for RA for at least a 4 month duration.
• Moderately to severely active RA based on local standard of care.

You may not qualify if…

• Evidence of untreated or inadequately treated latent or active TB.

Where it is running

• Altoona Center for Clinical Research — Duncansville, Pennsylvania, United States
• Metroplex Clinical Research Center — Dallas, Texas, United States
• Rheumatology and Pulmonary Clinic — Beckley, West Virginia, United States
• University Clinical Center of the Republic of Srpska — Banja Luka, Bosnia and Herzegovina
• Health Center Gradiska — Gradiska, Bosnia and Herzegovina
• Clinical Center University of Sarajevo — Sarajevo, Bosnia and Herzegovina
• General Hospital Prim. Dr.Abdulah Nakas — Sarajevo, Bosnia and Herzegovina
• UMHAT "Dr Georgi Stranski" EAD — Pleven, Bulgaria
• DCC Sveti Georgi — Plovdiv, Bulgaria
• Unimed Medical Centre — Plovdiv, Bulgaria
• IMEDICA s.r.o. — Brno, Czechia
• Lekarna Na Lidicke — Brno, Czechia
• Lekarna Biovita — Brno, Czechia
• X-Medica, s.r.o. — Brno, Czechia
• Revmacentrum MUDr. Mostera, s.r.o. — Brno, Czechia
• L.K.N. Arthrocentrum, s.r.o. — Hlučín, Czechia
• Plicni ambulance — Hlučín, Czechia
• Chirurgie Sibenik — Olomouc, Czechia
• CTCenter MaVe s.r.o — Olomouc, Czechia
• Lekarna u Pottingea — Olomouc, Czechia
• Lekarna Vesalion — Ostrava, Czechia
• CCR Czech a.s. — Pardubice, Czechia
• Lekarna BENU — Pardubice, Czechia
• Lekarna Pod Platany — Prague, Czechia
• Graves Gilbert Clinic — Bowling Green, Kentucky, United States

Full record on ClinicalTrials.gov

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