COMPuter-assisted Self-training to Improve EXecutive Function

Recruiting now · Not applicable

Conditions studied: Parkinson Disease, Stroke, Cardiac Arrest, Cognitive Dysfunction, Executive Dysfunction

In brief

This project explores the effects of specialized computer-based cognitive rehabilitation (CBCR) targeting executive functions in three groups of patients: Stroke, Cardiac Arrest and Parkinson's Disease. The effect of specialized CBCR is compared to generally cognitively stimulating activities on a computer

Key facts

Study ID

NCT04229056

Run by

Bispebjerg Hospital

People needed

307

Starts

2020-06-01

Expected to finish

2026-06-30

Last updated by the study team

2025-02-20

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A diagnose of stroke, cardiac arrest or Parkinson's disease.
• Aged 18 years or older.
• Impaired working memory measured with CABPad working memory test, cut off for inclusion: 5 symbols or less backwards
• Computer and internet access at home.
• Providing informed consent.
• Inclusion criteria specific for stroke
• Inclusion within 6 months post-stroke
• Stroke confirmed by clinical findings and imaging, both AIS and ICH is allowed.
• Initial stroke severity >/= NIHSS 3.
• Inclusion criteria specific for cardiac arrest
• Inclusion within 6 months post ictus.
• Inclusion criteria specific for Parkinson's disease
• Clinical diagnosis of PD.
• Anti-parkinsonian medical treatment (dopaminergic or other).

You may not qualify if…

• Informed consent not provided
• Other neurological or psychiatric disease which is expected to influence the patient's ability to participate in the trial according to the investigator
• Not able to participate according to investigator
• Exclusion criteria specific for stroke
• Patients with massive anosognosia for executive dysfunction or patients with no subjective feeling of executive dysfunction (Patient sustains total denial of executive symptoms over time)
• Patients with severe aphasia, in which it is unclear whether the patient's performance on a neuropsychological test-battery is due to aphasia and not executive dysfunction.
• Exclusion criteria specific for cardiac arrest • None
• Exclusion criteria specific for PD
• Diagnosis of PD Dementia according to the MDS PD Dementia criteria

Where it is running

• Bispebjerg Hospital — Copenhagen, Denmark (enrolling)
• Rigshospitalet — Copenhagen, Denmark (enrolling)

Full record on ClinicalTrials.gov

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