Genotypic Influences on Network Progression in Parkinson's Disease

Running, not enrolling

Conditions studied: Parkinson's Disease

In brief

In this longitudinal study, the investigators will follow Parkinson's disease (PD) patients with and without glucocerebrosidase (GBA) mutations. The investigators hypothesize that the rate of increase in brain network activity over time (network progression rate) is faster in patients with GBA gene mutations.

Key facts

Study ID

NCT04228172

Run by

Northwell Health

People needed

32

Starts

2020-02-24

Expected to finish

2026-10-06

Last updated by the study team

2026-04-13

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of PD made according to United Kingdom (UK) Parkinson's Disease Society Brain Bank Criteria
• Ability to provide written informed consent
• Age 40-75
• Stable dose of antiparkinsonian medication for >1 month prior to study entry

You may not qualify if…

• Subjects with pathogenic mutations in LRRK2 related PD mutations (subjects with variants of uncertain significance (VUS) are eligible
• History of known causative factors such as encephalitis or neuroleptic treatment
• Patients with dementia (defined as Mini-Mental Status Exam score <24 or a Telephone Interview for Cognitive Status score <26)
• Atypical parkinsonian features including oculomotor abnormalities, incontinence, ataxia, sensory loss, or pyramidal signs
• Known structural brain lesions
• Patients with history of stroke, head injury, high intracranial pressure or severe headaches
• Psychiatric disorder, including a history of major depression in the past 36 months
• Pregnant or breastfeeding women (female subjects of child-bearing potential will be screened for pregnancy before imaging).

Where it is running

• Feinstein Institutes for Medical Research — Manhasset, New York, United States

Full record on ClinicalTrials.gov

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