A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies

Recruiting now · Phase 1

Conditions studied: Myelodysplastic Syndrome, Acute Myeloid Leukemia

In brief

This trial will look at a drug called SEA-CD70 with and without azacitidine, to find out if it is safe for participants with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It will study SEA-CD70 to find out what its side effects are and if it works for AML and MDS. A side effect is anything the drug does besides treating cancer. This study will have seven groups or "parts." * Part A will find out how much SEA-CD70 should be given to participants * Part B will use the dose found in Part A to find out how safe SEA-CD70 is and if it works to treat participants with MDS. * Part C will use the dose found in Part A to find out how safe SEA-CD70 is and if it works to treat participants with AML. * Part D will find out how much SEA-CD70 with azacitidine should be given to participants * Part E will use the dose found in Part D to find out how safe SEA-CD70 with azacitidine is and if it works to treat participants with MDS or MDS/AML that has not been treated. * Part F will use the dose found in Part D to find out how safe SEA-CD70 with azacitidine is and if it works to treat participants with MDS or MDS/AML. * Part G will find out how much SEA-CD70 with azacitidine and with venetoclax should be given to participants with AML. Also, to evaluate safety and tolerability of PF-08046040 in combination with azacitidine and venetoclax in participants with previously untreated AML who are unfit for standard induction chemotherapy.

Key facts

Study ID

NCT04227847

Run by

Seagen, a wholly owned subsidiary of Pfizer

People needed

178

Starts

2020-08-07

Expected to finish

2028-07-03

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• The University of Kansas Cancer Center - Medical Oncology Clinic — Kansas City, Missouri, United States (enrolling)
• The University of Kansas Cancer Center - Radiation Oncology Clinic — Kansas City, Missouri, United States (enrolling)
• Karmanos Cancer Institute — Detroit, Michigan, United States (enrolling)
• Karmanos Cancer Institute Weisberg Cancer Treatment Center — Farmington Hills, Michigan, United States (enrolling)
• Ronald Reagan UCLA Medical Center — Los Angeles, California, United States (enrolling)
• UCLA Hematology-Oncology Clinic — Los Angeles, California, United States (enrolling)
• City of Hope (City of Hope National Medical Center, City of Hope Medical Center) — Duarte, California, United States (enrolling)
• Dana Farber/Mass General Brigham Cancer Care, Inc — Boston, Massachusetts, United States (enrolling)
• IP Address: City of Hope Investigational Drug Services(IDS) — Duarte, California, United States (enrolling)
• The University of Kansas Cancer Center ,Investigational Drug Services — Fairway, Kansas, United States (enrolling)
• The University of Kansas Clinical Research Center — Fairway, Kansas, United States (enrolling)
• The University of Kansas Hospital — Kansas City, Kansas, United States (enrolling)
• University of Kansas Hospital Cambridge North Tower A — Kansas City, Kansas, United States (enrolling)
• University of Kansas Medical center Medical office building — Kansas City, Kansas, United States (enrolling)
• University of Kansas Medical Center Research Institute — Kansas City, Kansas, United States (enrolling)
• The University of Kansas Cancer Center - Overland Park — Overland Park, Kansas, United States (enrolling)
• The University of Kansas Cancer Center - Indian Creek Campus — Overland Park, Kansas, United States (enrolling)
• The University of Kansas Cancer Center — Westwood, Kansas, United States (enrolling)
• Norton Hospitals, Inc — Louisville, Kentucky, United States (enrolling)
• Norton Cancer Institute, St. Matthews Campus, Attn. Becky Champion, PharmD — Louisville, Kentucky, United States (enrolling)
• Norton Cancer Institute, St. Matthews Campus — Louisville, Kentucky, United States (enrolling)
• Norton Women & Children's Hospital — Louisville, Kentucky, United States (enrolling)
• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States (enrolling)
• The University of Kansas Cancer Center -North — Kansas City, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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