Sufentanil Infusion vs Sufentanil Bolus

Completed · Phase 4

Conditions studied: Anesthesia

In brief

Randomized single blind controlled clinical trial to test the benefit of sufentanil infusion over bolus dosing to reduce time to extubation and reduced length of ICU stay.

Key facts

Study ID

NCT04226495

Run by

University of Nebraska

People needed

65

Starts

2020-10-13

Expected to finish

2021-10-28

Last updated by the study team

2026-06-08

Who can join

Age: 19 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Scheduled non-emergency cardiac surgical patients including those with planned procedures of CABG, AVR, and combined CABG and AVR
• 19 to 80 years old
• Planned pre-operative anesthesia screening visit and/or preoperative surgical clinic visit.
• Inpatient subject that is scheduled (greater than 24hrs in advance) for a non-emergency cardiac surgical case

You may not qualify if…

• Sufentanil allergy
• EF less than or equal to 30%
• Moderate or severe right ventricular dysfunction,
• Moderate pulmonary dysfunction, to include patients with at home 02 and/or daily bronchodilator therapy.
• End Stage Renal Disease on Dialysis
• Chronic Kidney Disease with GFR <30
• Sternotomy Re-do
• Emergency surgery
• Greater than 4 units of RBCs or FFP combined
• Mechanical circulatory support post-operatively such as ECMO, IABP, Impella
• Not eligible for rapid wean extubation protocol
• Requires infusion of sedative medication required during ICU admission
• Greater than or equal to 15 minute ICU hold within PACU

Where it is running

• University of Nebraska Medical Center — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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