Early Use of Airway Pressure Release Ventilation (APRV) in ARDS

Recruiting now · Not applicable

Conditions studied: Acute Respiratory Distress Syndrome

In brief

Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode. The investigators aim to compare APRV with conventional mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS).

Key facts

Study ID

NCT04221737

Run by

Hospital Civil de Guadalajara

People needed

150

Starts

2017-07-15

Expected to finish

2026-01-01

Last updated by the study team

2025-03-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute respiratory distress syndrome, according to the Berlin definition of ARDS, with adjusted pO2/FiO2 for altitude <300, and less than 48 h of endotracheal mechanical ventilation

You may not qualify if…

• Pregnancy
• Less than 18 years-old
• Expected duration of mechanical ventilation less than 48 h
• Preexisting conditions with an expected 3-month mortality exceeding 50%
• Concurrent chemotherapy
• Confirmed intracranial hypertension
• Catastrophic cranial trauma or neuromuscular disorders that are known to prolong mechanical ventilation
• Pneumothorax at enrollment (resolved or not)
• Do-not-resuscitate order

Where it is running

• Hospital Civil Fray Antonio Alcalde — Guadalajara, Jalisco, Mexico (enrolling)

Full record on ClinicalTrials.gov

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