Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

Completed · Not applicable

Conditions studied: Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain

In brief

A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.

Key facts

Study ID

NCT04217551

Run by

University of Michigan

People needed

1158

Starts

2020-05-18

Expected to finish

2026-02-01

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Coma after resuscitation from out of hospital cardiac arrest
• Cooled to <34 deg C with 240 minutes of cardiac arrest
• Definitive temperature control applied
• Age ≥ 18 years
• Informed consent from legal authorized representative (LAR) including intent to maintain life support for 96 hours
• Enrollment within 6 hours of initiation of cooling

You may not qualify if…

• Hemodynamic instability
• Pre-existing neurological disability or condition that confounds outcome determination
• Pre-existing terminal illness, unlikely to survive to outcome determination
• Planned early withdrawal of life support
• Presumed sepsis as etiology of arrest
• Prisoner

Where it is running

• Banner University Medical Center — Tucson, Arizona, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Ronald Regan UCLA Medical Center — Los Angeles, California, United States
• UC Davis Medical Center — Sacramento, California, United States
• UC San Diego Medical Center - Hillcrest — San Diego, California, United States
• Zuckerberg San Francisco General Hospital — San Francisco, California, United States
• Stanford University Medical Center — Stanford, California, United States
• Harbor-UCLA Medical Center — Torrance, California, United States
• University of Colorado Hospital — Aurora, Colorado, United States
• Denver Health Medical Center — Denver, Colorado, United States
• Yale New Haven Hospital — New Haven, Connecticut, United States
• George Washington University Hospital — Washington D.C., District of Columbia, United States
• UF Health Shands Hospital — Gainesville, Florida, United States
• Grady Memorial Hospital — Atlanta, Georgia, United States
• The Queen's Medical Center — Honolulu, Hawaii, United States
• Northwestern Memorial Hospital — Chicago, Illinois, United States
• Rush University Medical Center — Chicago, Illinois, United States
• University of Illinois-Chicago Hosptial — Chicago, Illinois, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Advocate Christ Medical Center — Oak Lawn, Illinois, United States
• IU Health Methodist Hospital — Indianapolis, Indiana, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Kentucky Hospital — Lexington, Kentucky, United States
• Maine Medical Center — Portland, Maine, United States
• University of Alabama Hospital — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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