Semantic Feature Analysis Treatment for Aphasia
Running, not enrolling · Not applicable
Conditions studied: Aphasia
In brief
This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.
Key facts
- Study ID
- NCT04215952
- Run by
- VA Pittsburgh Healthcare System
- People needed
- 40
- Starts
- 2020-02-24
- Expected to finish
- 2025-08-30
- Last updated by the study team
- 2025-06-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 6 months post-onset of aphasia due to unilateral left-hemisphere (LH) stroke
- Independent in activities of daily living (ADLs) necessary to live in community-based housing or available caregiver to assist with ADLs
- Medically stable and able to tolerate intensive treatment schedule (e.g. no uncontrolled seizures, difficulty breathing, frequent migraines)
- English as a first language
- No participation in any other speech-language treatment during this study, including follow-up period
- Sufficient auditory comprehension abilities demonstrated during screening
- Sufficient naming impairment exhibited during screening
You may not qualify if…
- Right Hemisphere stroke
- Neurological disease other than stroke
- Significant psychiatric disorder
- Severe motor speech disorder
- Active substance dependence
Where it is running
- VA Pittsburgh Healthcare System — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.