Childhood Allergy and the Neonatal Environment

Running, not enrolling

Conditions studied: Asthma in Children, Allergy

In brief

The purpose of this research study is to study the relationship between childhood asthma, allergies, and early-life environmental factors that may cause childhood asthma and allergies. Previous birth cohort studies have found early-life environmental factors such as allergies, pollutants, viruses and bacteria have all contributed to the development of asthma and allergies. Investigators are doing this research because there continues to be a strong need to understand the root causes of asthma and allergies. The CANOE study is an observational cohort study, which means investigators are not asking participants or participant's child to change their medications and investigators will not be giving participants or participant's child a study drug.

Key facts

Study ID

NCT04215783

Run by

University of Wisconsin, Madison

People needed

499

Starts

2020-03-04

Expected to finish

2027-08-31

Last updated by the study team

2026-02-10

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of or concurrent asthma or allergic rhinitis (hay fever) in either biologic parent or sibling (at least one shared biological parent) by parental report. The presence of paternal or sibling allergy or asthma will be ascertained by maternal report.
• Maternal age greater than or equal to 18 years at the time of study enrollment.

You may not qualify if…

• Maternal HIV infection at time of delivery.
• Plans for the family to move out of the geographic area during the period of the study.
• Does not speak English.
• Current maternal use of progesterone during pregnancy to prevent preterm birth.
• Progesterone use is only an exclusion if currently being taken at time of enrollment for preterm birth. Previous use to prevent preterm birth or use at any time for other indications is allowed.
• Pregnancy is a result of an embryo donor (egg and sperm donor pregnancies are permitted).
• Past or current medical problems or findings from physical examination or laboratory testing which, in the opinion of the investigator or designee, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

Where it is running

• Henry Ford Health Systems — Detroit, Michigan, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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