Losartan to Improve Hip Microfracture
Stopped early · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Hip Osteoarthritis, Hip Impingement Syndrome, Cartilage Damage, Fibrosis
In brief
Phase I/IIA randomized, double-blind, placebo-controlled clinical trial to assess safety and efficacy of oral losartan for improving cartilage repair following microfracture to treat focal cartilage defects during hip arthroscopy.
Key facts
- Study ID
- NCT04212650
- Run by
- Steadman Philippon Research Institute
- People needed
- 1
- Starts
- 2020-08-07
- Expected to finish
- 2020-12-04
- Last updated by the study team
- 2023-10-30
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Underwent primary hip arthroscopy
- Underwent baseline quantitative MRI at The Steadman Clinic (TSC)
- Single, localized, grade 3 or 4 cartilage lesion of the acetabulum or femoral head treated with Bone Marrow Stimulation (BMS; i.e. microfracture)
- Aged 18-60 at time of surgery
- Tonnis grade 1 or less
You may not qualify if…
- Two or more cartilage lesions of grade 3 or 4
- Less than 2 mm of minimal hip joint space
- Osteoarthritis or diffuse change of cartilage
- Non-English speaking
- Prior hip surgery on operative hip
- Pre-existing bony deformity caused by previous fracture(s)
- Synovial chondromatosis
- Pigmented Villonodular Synovitis (PVNS)
- Dysplasia (center edge angle <20 degrees)
- History of Avascular Necrosis (AVN), Perthes disease, or slipped capital femoral epiphysis (SCFE)
- Inflammatory arthritis or other arthritis caused by autoimmune disease
- Patients allergic to any active or inactive ingredient of losartan
- Patients taking medication with known losartan interaction, including phenobarbital, rifampin, and fluconazole.
- Subjects that are currently taking losartan
Where it is running
- Steadman Philippon Research Institute — Vail, Colorado, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.