Thrombus Aspiration in STEMI Patients With High Thrombus Burden

Recruiting now · Not applicable

Conditions studied: ST-segment Elevation Myocardial Infarction (STEMI)

In brief

This is a prospective, multicenter, open-label, randomized, controlled, parallel group study, in which ST-segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(TIMI thrombus grade ≥3) are included. Patients are randomized to be treated with or without manual thrombus aspiration(TA) during primary percutaneous coronary intervention(PPCI) by a ratio of 1:1.

Key facts

Study ID

NCT04212494

Run by

Guangdong Provincial People's Hospital

People needed

3838

Starts

2020-08-30

Expected to finish

2026-02-28

Last updated by the study team

2024-11-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years;
• STEMI patients undergoing primary PCI within 12 hours after the onset of symptoms;
• High thrombus burden after guidewire passes the lesion (TIMI thrombus grade ≥3);
• Informed consent must be voluntary;

You may not qualify if…

• Haemodynamic instability or cardiogenic shock;
• After thrombolytic therapy;
• The predicted survival time is less than 6 months due to non-cardiac disease;
• History of coronary artery bypass grafting;
• Participate in other researches within 30 days;
• Preoperative gastrointestinal bleeding or contraindications to dual antiplatelet therapy;
• Patients were considered unsuitable by other researchers.

Where it is running

• The Second Affiliated Hospital of Shantou university Medical College — Shantou, Guangdong, China (enrolling)
• Kaiping Central Hospital — Kaiping, Guangdong, China (enrolling)
• People's Hospital of Yangjiang City — Yangjiang, Guangdong, China (enrolling)
• The Second People's Hospital of Nanhai District — Foshan, Guangdong, China (enrolling)
• Sihui people's Hospital — Zhaoqing, Guangdong, China (enrolling)
• Guangzhou General Hospital of Guangzhou Military Command — Guangzhou, Guangdong, China
• The first Affiliated Hospital, Sun Yat-Sen University — Guangzhou, Guangdong, China
• Guangdong Provincial Hospital of traditional Chinese Medicine — Guangzhou, Guangdong, China
• The First Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China
• The Second Affiliated Hospital, Sun Yat-Sen University — Guangzhou, Guangdong, China
• Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong, China
• Nanfang Hospital — Guangzhou, Guangdong, China
• Huangpu Division of The First Affiliated Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China
• Huadu District People's Hospital of Guangzhou — Guangzhou, Guangdong, China
• Huizhou Third People's Hospital — Huizhou, Guangdong, China
• Jiangmen Central Hospital — Jiangmen, Guangdong, China
• Maoming People's Hospital — Maoming, Guangdong, China
• Yue Bei People's Hospital — Shaoguan, Guangdong, China
• Shenzhen People's Hospital — Shenzhen, Guangdong, China
• The Eighth Affiliated Hospital, Sun Yat-Sen University — Shenzhen, Guangdong, China
• Peking University Shenzhen Hospital — Shenzhen, Guangdong, China
• Shenzhen Bao'an District People's Hospital — Shenzhen, Guangdong, China
• Taishan people's Hospital — Taishan, Guangdong, China
• Nanxiong people's Hospital — Xiongzhou, Guangdong, China
• The Second Affiliated Hospital of Guangdong Medical University — Zhanjiang, Guangdong, China

Full record on ClinicalTrials.gov

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