Nasal Decolonization of Dialysis Patients Noses

Running, not enrolling · Phase 4

Conditions studied: Staphylococcus Aureus Infection

In brief

Hemodialysis patients are at high-risk for infections, specifically Staphylococcus aureus infections. The investigators propose to 1) implement a novel intervention (nasal povidone-iodine at each hemodialysis session) to prevent S. aureus infections using a stepped-wedge cluster randomized trial, and 2) evaluate the feasibility and acceptability of this intervention. If successful, this intervention can be used among hemodialysis patients, and evaluated in other high-risk patient populations to prevent S. aureus infections.

Key facts

Study ID

NCT04210505

Run by

Marin L. Schweizer, PhD

People needed

302

Starts

2020-09-29

Expected to finish

2024-01-31

Last updated by the study team

2023-06-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients receiving outpatient chronic hemodialysis at one of the 16 study dialysis centers.
• Note: the unit of randomization is the dialysis center, not the individual patient

You may not qualify if…

• Patients receiving peritoneal dialysis or home hemodialysis Pregnant women Patients with known sensitivity or allergy to iodine (documented or verbalized) Patients with active bacterial infections Children < 18 years of age. Patients with infections at the beginning of the study will enter the study after antibiotic treatment is complete.

Where it is running

• Emory Healthcare — Atlanta, Georgia, United States
• University of Illinois Chicago — Chicago, Illinois, United States
• University of Iowa — Iowa City, Iowa, United States
• Washington University — St Louis, Missouri, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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