Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants

Completed · Not applicable

Conditions studied: Premature Lungs, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal

In brief

This study is being conducted to determine whether prophylactic administration of surfactant by the Less Invasive Surfactant Administration (LISA) method reduces the need for mechanical ventilation in the first 72 hours of life when compared to early Continuous Positive Airway Pressure (CPAP) alone.

Key facts

Study ID

NCT04209946

Run by

Sharp HealthCare

People needed

180

Starts

2020-01-22

Expected to finish

2025-11-10

Last updated by the study team

2025-12-18

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Premature infants born at 24 to 29+6 weeks gestation
• Informed consent obtained (antenatal)
• Infant is spontaneously breathing on CPAP of 5-8 cmH2O and maintaining a normal heart rate (HR>100 Bpm)

You may not qualify if…

• Declined consent
• Infants with known congenital anomalies
• Unstable immediately after birth, requiring intubation in the delivery room

Where it is running

• University of California, Irvine — Irvine, California, United States
• Loma Linda Medical Center — Loma Linda, California, United States
• Sharp Mary Birch Hospital for Women & Newborns — San Diego, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.