A Study of BDTX-189, an Orally Available Allosteric ErbB Inhibitor, in Patients With Advanced Solid Tumors.
Stopped early · Phase 1
Conditions studied: Solid Tumor
In brief
This was a clinical study with an orally administered drug, BDTX-189 in participants with advanced solid tumors that had select mutations or alterations in human epidermal growth factor receptor 2 (HER2/ErbB2) genes or epidermal growth factor receptor (EGFR/ErbB1). The main goals of this study were to: * Find the recommended dose of BDTX-189 that can be given safely to participants * Learn more about the side effects of BDTX-189 * Learn what the body does to BDTX-189 after it has been taken (pharmacokinetics or PK) * Determine the preliminary antitumor activity of BDTX-189 in participants with select allosteric ErbB gene mutations
Key facts
- Study ID
- NCT04209465
- Run by
- Black Diamond Therapeutics, Inc.
- People needed
- 91
- Starts
- 2019-12-19
- Expected to finish
- 2022-09-16
- Last updated by the study team
- 2025-04-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- 9250 — Scottsdale, Arizona, United States
- 9405 — Long Beach, California, United States
- 9474 — Orange, California, United States
- 7141 — New Haven, Connecticut, United States
- 4080 — Lake Mary, Florida, United States
- 4100 — Orlando, Florida, United States
- 9535 — Plantation, Florida, United States
- 4060 — Sarasota, Florida, United States
- 9035 — Atlanta, Georgia, United States
- 9530 — Rolling Meadows, Illinois, United States
- 9092 — New Orleans, Louisiana, United States
- 9203 — Boston, Massachusetts, United States
- 9209 — Buffalo, New York, United States
- 9215 — New York, New York, United States
- 9236 — New York, New York, United States
- 9264 — Portland, Oregon, United States
- 7122 — Pittsburgh, Pennsylvania, United States
- 4107 — Chattanooga, Tennessee, United States
- 3000 — Nashville, Tennessee, United States
- 9003 — Dallas, Texas, United States
- 9117 — Houston, Texas, United States
- 9538 — Webster, Texas, United States
- 9112 — Fairfax, Virginia, United States
- 9173 — Milwaukee, Wisconsin, United States
- 9500 — Copenhagen, Denmark
Full record on ClinicalTrials.gov
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