Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients
Stopped early · Not applicable
Conditions studied: Infertility, Male
In brief
The purpose of this study is to compare semen parameters with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) when male factor infertility patients abstain from ejaculation more than 48 hours (routine care) or less than 24 hours from the day of the partner's oocyte retrieval. The investigators hypothesize that total motile sperm count will be improved with ejaculatory abstinence (EA) less than 24 hours. Information from this trial could allow investigators to optimize chances for a successful pregnancy in patients who need IVF/ICSI.
Key facts
- Study ID
- NCT04206800
- Run by
- Boston IVF
- People needed
- 5
- Starts
- 2020-01-20
- Expected to finish
- 2020-07-15
- Last updated by the study team
- 2020-09-25
Who can join
Age: 18 and older, up to 50. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Male Age 18 - 50 years and female age < 38 years
- First IVF cycle
- Abnormal semen parameters (at least 1 of the following on 2 semen analysis with at least one being in the past 12 months): a) sperm concentration < 10 million/mL; b) unprocessed semen analysis with < 10 million motile sperm or processed semen analysis with < 3 million motile sperm; c) < 2 % normal forms (strict Kruger morphology)
- Female AMH > 0.7 and/or and day 2-4 FSH < 12
You may not qualify if…
- Donor sperm
- Males with less than 200,000/mL sperm in the ejaculate
- Utilization of a gestational carrier
- Frozen donor egg
- Female morbid obesity: BMI > 40
- History of recurrent pregnancy loss (≥2 spontaneous abortions)
- Preimplantation genetic testing - (M or SR) Monogenetic disorders or chromosomal rearrangement
- The use of non-ejaculated sperm (testicular sperm extraction)
Where it is running
- Boston IVF — Waltham, Massachusetts, United States
Full record on ClinicalTrials.gov
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