Effect of Stimulation on the Vagus Nerve

Running, not enrolling · Not applicable

Conditions studied: Healthy Subjects

In brief

The vagus nerve is a largely-internal nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve. If it does, then investigators hope that this will help the treatment of patients with nausea and vomiting and disordered stomach function. Investigators also hope to be able to measure the activity of the vagus nerve when it is stimulated in other ways. This could help investigators learn more about studying this nerve in the future.

Key facts

Study ID

NCT04206540

Run by

Indiana University

People needed

30

Starts

2019-07-22

Expected to finish

2027-08-31

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers
• Aged 18-80 years
• Willing to have electrodes placed in the external ear (ABVN arm)
• Willing to perform vagal activity maneuver ( Vagal arm)

You may not qualify if…

• Unable to provide consent
• Having gastric motility issues as determined by the PI or Sub I
• Taking medications affecting gastric motility
• Pregnant females
• Prisoners

Where it is running

• Indiana University Hosptial — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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