Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline

Status unconfirmed · Phase 2 · Has a placebo group

Conditions studied: Allergic Rhinitis, Asthma

In brief

Adults with known respiratory allergy/asthma with known skin test sensitization will undergo repeat skin prick testing at 4 areas of both arms (bilateral forearms, bilateral upper arms). Each site will be challenged with up to three known allergens, saline and histamine controls. Mean wheal diameter after 20 minutes challenge will be determined. This is followed by placement of minocycline cream (0%, 1%, 2%, 3%), placed in randomized fashion at each of 1 of 4 skin test sites. Measurement of subsequent wheal diameter will be done at 30 minutes, 60 minutes and 24 hours.

Key facts

Study ID

NCT04202263

Run by

State University of New York - Downstate Medical Center

People needed

25

Starts

2019-09-26

Expected to finish

2023-09-25

Last updated by the study team

2021-10-14

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult ( ages 18-75) outpatients with diagnosis of allergic rhinoconjunctivitis and/or asthma who have previously undergone epicutaneous skin prick testing with detection of at least one allergen positive.

You may not qualify if…

• Subjects who are unable/unwilling to undergo cessation of oral antihistamines for five days prior to testing.
• Current use of oral steroids or other systemic immunosuppressants, including omalizumab (anti-IgE therapy) and anti-IL-5 therapy.
• Allergic asthmatics who have current uncontrolled asthma.

Where it is running

• SUNY Downstate Medical Center — Brooklyn, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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