Signature of the Risk Profile of Mortality in a Hospital Cohort of Patients With Metabolic Diseases

Recruiting now

Conditions studied: Metabolic Disease

In brief

Epidemiological studies are usually conducted in the general population in adults without complications or pathology at baseline. The results obtained are therefore often better designed for primary prevention use. The prediction of mortality risk in patients with complications and requiring hospital follow-up is less well known. The study purpose is to determine a mortality risk profile in a hospital cohort of patients with pathologies associated with metabolic diseases. Today the "multimaker" scores based on a panel of biomarkers - have significantly improved the discriminating power of prediction models existing in many pathologies. It is no longer a single biomarker that can improve risk prediction but a complete and cross-sectional profile that is sought after. We aim to establish a personalised mortality risk profile by combining clinical and biological parameters including metabolomics, genetics, transcriptomics and epigenomics by high throughput screening of biological samples.

Key facts

Study ID

NCT04194372

Run by

University Hospital, Lille

People needed

10000

Starts

2019-12-20

Expected to finish

2030-01-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diabetic: antecedent - treatment - or glycemia> = 1.26 g / dl - or HbA1C> = 6.5% and or
• Obese: BMI> = 30 and or
• Metabolic syndrome defined AND
• Patient having given written consent to participate in the study or collection of the consent of the witness
• Social insured patient (excluding AME)
• Patient willing to comply with all procedures of the study and its duration AND
• Patient also presenting a pathology among:
• Cardiology:
• Coronary patient(history of myocardial infarction, coronary bypass, or coronary angioplasty or stenosis greater than 50% on an epicardial vessel documented on coronary angiography)
• Patient with systolic or diastolic heart failure
• Patient with atrial fibrillation
• Patient with aortic stenosis (Vmax> 2.5 m / s)
• Patient with high blood pressure
• neurology:
• ischemic stroke
• intracerebral hemorrhage
• transient ischemic attack
• diabetology:
• Obesity without diabetes
• Diabetes T2
• T1 diabetes
• Monogenic Diabetes / MODY
• African Diabetes
• Diabetes secondary to pancreatopathy / liver cirrhosis
• Diabetes post transplantation / post immunotherapy

You may not qualify if…

• Unscheduled hospitalization less than 3 months old
• Ongoing treatment :
• Cytotoxic chemotherapy
• Radiotherapy
• HIV and / or HCV and / or active HBV infection
• OMS score> = 2
• Pregnant woman

Where it is running

• Ch Boulogne-Sur-Mer — Boulogne-sur-Mer, France (enrolling)
• Hop Cardiologique Chr Lille — Lille, France (enrolling)
• Hop Claude Huriez Chr Lille — Lille, France (enrolling)

Full record on ClinicalTrials.gov

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