High Definition Colonoscopy (HDC) vs. Dye Spraying Chromo-colonoscopy (DSC) in Screening Patients With Long-standing Inflammatory Bowel Disease (IBD)
Completed · Not applicable
Conditions studied: Inflammatory Bowel Diseases, Colon Dysplasia, Ulcerative Colitis, Crohn Colitis, Indeterminate Colitis
In brief
Inflammatory Bowel Disease (IBD) involving the colon is a known risk for colon cancer. There are two standards-of-care colonoscopy techniques used for screening all patients who suffer from IBD for more than eight years. One method is to obtain random biopsies throughout the colon and the other is by using dye spraying chromo-colonoscopy. This trial aims to study the difference between the two colonoscopy techniques during the era of high definition camera in detecting neoplastic lesions during screening patients with long-standing IBD.
Key facts
- Study ID
- NCT04191655
- Run by
- Beth Israel Deaconess Medical Center
- People needed
- 211
- Starts
- 2019-04-03
- Expected to finish
- 2024-01-01
- Last updated by the study team
- 2026-03-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient age ≥18yr old
- History of UC or colonic Crohn's disease or unclassified colitis patients with or without colonic adenoma history
- Duration of ≥ eight years since diagnosis, or any duration with a diagnosis of primary sclerosing cholangitis
- Mucosal lesion involves ≥ 1/3 of the colon
You may not qualify if…
- History of colorectal cancer
- History of total colectomy
- Prior colonoscopy within the last 6 months
- Allergy to dye spray
- Poor bowel preparation
- Unable to provide informed consent
- Severe inflammation preventing visualization of the mucosa during the procedure.
Where it is running
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Lahey Hospital and Medical Center — Burlington, Massachusetts, United States
Full record on ClinicalTrials.gov
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