Pain, Inflammation and Opioid Craving

Completed · Not applicable

Conditions studied: Opioid-use Disorder

In brief

The goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder. In this study, adults with opioid use disorder will be randomized to one of two brief education sessions followed by an assessment of response to pain. Investigators will test the association between response to pain and opioid craving.

Key facts

Study ID

NCT04190563

Run by

Mclean Hospital

People needed

89

Starts

2021-05-04

Expected to finish

2025-07-31

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 18 years or older;
• diagnosis of opioid use disorder
• chronic pain
• ability to read and provide informed consent

You may not qualify if…

• major psychiatric or medical condition that would interfere with participation
• current opioid withdrawal
• currently receiving opioid analgesic medication for pain
• recent history of myocardial infarction or other serious cardiovascular condition
• current peripheral neuropathy, active vasculitis or severe peripheral vascular disease
• systematic inflammatory or autoimmune disorder
• admitted to current treatment episode on an involuntary status

Where it is running

• McLean Hospital — Belmont, Massachusetts, United States

Full record on ClinicalTrials.gov

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