Computational Psychiatric Approach to Depression
Completed
Conditions studied: Depression, Treatment Resistant Depression
In brief
The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression. Subjects will be invited to be in this study because (1) they are a patient about to receive ECT treatment for depression, or (2) they are a patient diagnosed with depression and do not qualify for ECT treatment, or (3) they are a healthy adult volunteer with no history of depression. All volunteers must be between the ages of 18-85. Participation in this research will involve three visits. Each visit will last about 3-4 hours. If the subject is a patient receiving ECT for depression the study team will schedule study visits to go along with patient treatment visits. If the subject is diagnosed with depression (not treatment-resistant depression) or are a healthy volunteer, their first visit will be scheduled at their convenience, followed by a second visit 1-3 months post visit one and a third visit 1-2 months post visit two, for a total of three research visits. Participation in this research will involve playing simple computer games while the subject's brain is scanned with magnetic resonance imaging (MRI). Additionally, the study team will assess symptoms of depression using questionnaires. Patients receiving ECT will not experience any changes to their standard of care ECT treatment plan. Healthy and non-treatment resistant depressed volunteers will not undergo ECT treatment.
Key facts
- Study ID
- NCT04189939
- Run by
- Wake Forest University Health Sciences
- People needed
- 128
- Starts
- 2020-03-09
- Expected to finish
- 2023-07-10
- Last updated by the study team
- 2024-08-06
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult volunteers (ages 18-85)
- Treatment-resistant depressed patients must meet criteria in standard-of-care evaluation for ECT treatment
- Clinically depressed patients must meet criteria in standard-of-care evaluation for depression.
You may not qualify if…
- Individuals who cannot have MRI scanning
- Individuals not able to provide written consent and verbal assent
- Individuals not able to understand task instructions or consent documents
- Women who are pregnant
- For healthy subject volunteers:
- Inclusion Criteria:
- Healthy adult volunteers (ages 18-85)
- Exclusion Criteria:
- Individuals diagnosed with depression (regardless of treatment status)
- Individuals who cannot have MRI scanning
- Individuals not able to provide written consent and verbal assent
- Individuals not able to understand task instructions or consent documents
- Women who are pregnant
Where it is running
- Wake Forest School of Medicine — Winston-Salem, North Carolina, United States
Full record on ClinicalTrials.gov
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