Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study
Completed
Conditions studied: Hematopoietic and Lymphoid Cell Neoplasm
In brief
This trial observes and collects samples from patients before and after stem cell transplantation to learn more about how and why a complication called chronic graft-versus-host disease (GVHD) develops after stem cell transplantation. Performing close observation and various types of testing may enable doctors to notice symptoms or problems sooner than they would normally have been noticed and predict which patients will develop chronic GVHD.
Key facts
- Study ID
- NCT04188912
- Run by
- Fred Hutchinson Cancer Center
- People needed
- 267
- Starts
- 2019-09-13
- Expected to finish
- 2025-09-29
- Last updated by the study team
- 2025-10-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults age 18 or older
- Scheduled for allogeneic HCT from any donor for any indication, with a risk of cGVHD of > 25% (see below in exclusion criteria for treatment plans with a cGVHD risk < 25%)
- Ability and willingness to comply with the intensive assessment schedule including evaluation every other month at a participating site
- Ability to communicate in English or Spanish, to allow completion of patient surveys and clear communication with the study team
You may not qualify if…
- Receipt of umbilical cord blood, bone marrow with post-transplant cyclophosphamide (peripheral blood with post-transplant cyclophosphamide is allowed), anti-thymocyte globulin, alemtuzumab, or ex-vivo T-cell depletion. These patients are excluded because they have a cGVHD risk of < 25%
- Hematologic malignancy with active disease at the time of transplant. Minimal residual disease is allowed
- Hematopoietic cell transplant co-morbidity index > 4 based on parameters known at time of enrollment
- Prior allogeneic transplant
- Prior autoimmune disease with ongoing symptoms
- History of noncompliance
- Inability to comply with study requirements due to geographic, logistic, social or any other factors
Where it is running
- University of Florida — Gainesville, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- National Cancer Institute — Bethesda, Maryland, United States
- Roswell Park — Buffalo, New York, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- Vanderbilt — Nashville, Tennessee, United States
- Fred Hutch/University of Washington Cancer Consortium — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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