EEG Based BCI for Upper Limb Rehabilitation in Stroke

Status unconfirmed · Not applicable

Conditions studied: Stroke Sequelae, Brain Ischemia

In brief

Biomedical and Engineering approaches form a key element to neurological rehabilitation of upper limbs. Brain Computer Interface (BCI) using Motor execution and Motor Imagery are known to aid motor recovery in stroke. The purpose of this study is to demonstrate that Noninvasive Sensorimotor Rhythm (SMR) based EEG based BCI using motor execution and Motor Imagery tasks can aid in rehabilitation of upper limb movements in chronic stroke. The project aims to explore an SMR-based BCI system that can exploit the sensorimotor rhythm voluntary modulation to play a virtual game as neurofeedback using motor executory tasks and imagined hand movements by stroke patients, who suffer from upper limb disability.

Key facts

Study ID: NCT04188132
Run by: University of Houston
People needed: 10
Starts: 2019-11-05
Expected to finish: 2020-01-31
Last updated by the study team: 2019-12-05

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age: 21-75 years
Subacute or chronic stroke; interval of at least 3 months and interval of at least 6 months from stroke to time of enrollment, respectively.
no cerebellar signs or bilateral motor deficit
Cognitive ability to consent, assimilate, and participate actively in the treatment protocol (Mini Mental State Examination score > 24 points, out of a total 30 indicating normal cognitive ability);
Modified Rankin scale scores 1-3 (Mild-Moderate functional disability post-stroke);
Modified Ashworth Scale of Spasticity score <= 3 (ranges from 0-4 with 4 reflecting maximum spasticity)
No epilepsy /usage of antiepileptic drug
◦ Subjects with Stroke will be included if they have:
unilateral impaired upper limb
Able to initiate hand movements like opening and closing fist and no joint contracture or severe spasticity in the affected upper limbs.
Sufficient sitting balance to participate in experimental activities.
No condition (e.g. severe arthritis, central pain) that would interfere with the administration of motor function tests.
English-language comprehension and cognitive ability sufficient to give informed consent (MMSE >=24) and to cooperate with the intervention.

You may not qualify if…

• Orthopedic conditions of either upper or lower extremity that would affect performance on the study
untreated depression that may affect motivation to participate in the study
vascular cognitive impairment interfering with comprehending the tasks
Individuals with stroke who have been diagnosed with cognitive or severe visual deficits, hemineglect, uncontrolled angina, or pregnancy
no psychiatric or neurological condition other than stroke
◦ Stroke will be excluded if they have:
Pregnancy (Self -reported)
Dementia (MMSE score less than 24)
Recurrence of stroke (Occurrence of new focal deficits reported by patient or detected by PI on examination during visits)

Where it is running

Subasree Ramakrishnan — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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