Molecular Genetics Studies of Cancer Patients and Their Relatives

Recruiting now

Conditions studied: Malignant Neoplasm

In brief

This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.

Key facts

Study ID

NCT04185935

Run by

City of Hope Medical Center

People needed

999999

Starts

1997-04-18

Expected to finish

2033-08-18

Last updated by the study team

2026-06-29

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Individuals must have a personal history of cancer and/or a family history of cancer suggestive of the presence of an inherited predisposition. This inherited predisposition might manifest as:
• Young age cancer diagnosis
• Multiple primary neoplasms in affected member
• The presence of rare tumor types in the family
• Congenital malformations
• Any other family clustering of cancer
• Any other cancer-predisposing genetic diseases/conditions
• Individuals may also be eligible by participation in the City of Hope Cancer Screening \& Prevention Program Network (CSPPN) clinical service or on the basis of membership in a group known or suspected to have an increased risk of carrying a genetic alteration or of sustaining a particular exposure that would place that at increased risk of cancer. (Examples would include members of occupational cohorts like asbestos workers, individuals with multiple dysplastic nevi in the absence of a family history of cancer, and individuals descended from a particular tribe in the American Southwest who have an increased incidence of a rare genetic alteration associated with an increased risk of a specific cancer.)
• Individuals and families may be referred to us in a number of different ways. After initial contact is made with a individual or family by family studies personnel; an individual within the bloodline will be identified as the historian. There may be more than one historian within a family
• At least one historian must be wiling to provide information or access as needed to contact appropriate family members for documentation of cancer and for consent. An individual is considered to be eligible to participate if they criteria; contact with relatives is not always indicated
• Individuals who are under 18 are eligible for study if they meet the criteria. Consent for participation must be given by a legal guardian or parent
• Deceased patients may be included in the study. Public records, such as death certificates, can be used to confirm information from individuals or family members. If medical records are needed, consent for these records will be obtained from the deceased's next of kin. Next of kin refers to the following hierarchy of relatives; spouse, offspring, parents, and siblings. (Any further use of next of kin in this protocol should relate back to this hierarchy.) Archived tissue samples, such as pathology blocks or snap frozen tumor from a pathology department tumor bank (discard specimens) may be used for genetic research

You may not qualify if…

• A family may be ineligible for study if the historian will not allow access to anyone within the family and thus, the accuracy of the family history cannot be established

Where it is running

• University of Puerto Rico — San Juan, Puerto Rico (enrolling)
• John Muir Medical Center-Concord Campus — Concord, California, United States (enrolling)
• City of Hope Medical Center — Duarte, California, United States (enrolling)
• Saint Jude Medical Center — Fullerton, California, United States (enrolling)
• Saddleback Memorial Medical Center — Laguna Hills, California, United States (enrolling)
• USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States (enrolling)
• Saint Joseph Hospital - Orange — Orange, California, United States (enrolling)
• Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California, United States (enrolling)
• Cancer Center of Santa Barbara — Santa Barbara, California, United States (enrolling)
• Lynn Regional Cancer Center - West — Boca Raton, Florida, United States (enrolling)
• Holy Cross Hospital — Fort Lauderdale, Florida, United States (enrolling)
• Kootenai Cancer Center — Post Falls, Idaho, United States (enrolling)
• John H Stroger Jr Hospital of Cook County — Chicago, Illinois, United States (enrolling)
• Rush University Medical Center — Chicago, Illinois, United States (enrolling)
• Mercy Hospital — Cedar Rapids, Iowa, United States (enrolling)
• Suburban Hospital — Bethesda, Maryland, United States (enrolling)
• Frederick Oncology Hematology Associates — Frederick, Maryland, United States (enrolling)
• Steward Saint Elizabeth's Medical Center — Brighton, Massachusetts, United States (enrolling)
• Hunterdon Medical Center — Flemington, New Jersey, United States (enrolling)
• Lovelace Medical Center-Downtown — Albuquerque, New Mexico, United States (enrolling)
• New Mexico Oncology Hematology Consultants — Albuquerque, New Mexico, United States (enrolling)
• Presbyterian Kaseman Hospital — Albuquerque, New Mexico, United States (enrolling)
• Mount Kisco Medical Group at Northern Westchester Hospital — Mount Kisco, New York, United States (enrolling)
• Health Quest Medical Practice PC-Cardio Thoracic — Poughkeepsie, New York, United States (enrolling)
• Aultman Health Foundation — Canton, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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