COLO-COHORT (Colorectal Cancer Cohort) Study

Recruiting now

Conditions studied: Colorectal Cancer, Colorectal Adenoma, Colorectal Neoplasm, Predictive Cancer Model, Model

In brief

This is a cross-sectional study aimed at identifying factors which best predicts patients at high risk of colorectal cancer or colorectal adenomas and to develop a risk prediction model.

Key facts

Study ID

NCT04185779

Run by

South Tyneside and Sunderland NHS Foundation Trust

People needed

15000

Starts

2019-12-13

Expected to finish

2026-08-15

Last updated by the study team

2020-10-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Group A
• Aged ≥30 years* and able to give informed consent
• Patients attending colonoscopy
• Through Bowel Cancer Screening Programme (FIT positive, Bowelscope conversion, surveillance)
• Through standard NHS care (most commonly due to iron deficiency anaemia, altered bowel habit, weight loss, rectal bleeding, planned polypectomy**, those referred on basis of family history, abnormal cross-sectional imaging, polyp surveillance or post CRC surveillance)
• The age of 30 was chosen to ensure that this is a population likely to be enriched for colorectal neoplasia with neoplasia below this age uncommon **In those attending for planned polypectomy, the results from the initial colonoscopy and the endoscopy where the polypectomy is undertaken will be summated for purposes of calculating the neoplasia profile
• (COLO-SPEED) Group B
• Any patient attending for colonoscopy and able to give informed consent
• ≥ 18 years old
• Patient from the North of England

You may not qualify if…

• Group A
• Unable to give informed consent
• Known polyposis syndrome
• Previous total colectomy
• Known colonic stricture which would limit complete colonoscopy
• Attending for planned therapeutic procedure other than polypectomy, such as insertion of colonic stent
• Attending for assessment of known inflammatory bowel disease (IBD) activity or for IBD surveillance
• Patients currently recruited into an interventional CTIMP for CRC prevention*
• COLO-SPEED (Group B) **
• Unable to give informed consent
• Not in a centre supported by COLO-SPEED infrastructure (North of England)

Where it is running

• South Tyneside and Sunderland NHS Foundation Trust — South Shields, Tyne and Wear, United Kingdom (enrolling)
• North Tees and Hartlepool NHS Foundation Trust — Stockton-on-Tees, United Kingdom (enrolling)
• Kettering General Hospitals NHS Foundation Trust — Kettering, United Kingdom

Full record on ClinicalTrials.gov

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