Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Lumbar Disc Herniation

In brief

The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.

Key facts

Study ID

NCT04182997

Run by

University of Missouri-Columbia

People needed

200

Starts

2019-11-21

Expected to finish

2026-12-01

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Presenting to the University of Missouri hospital system - including the University of Missouri Hospital and Missouri Orthopaedic Institute - with a clinical assessment indicative of a lumbar disc herniation
• Failed conservative treatment - rest, anti-inflammatory medications, physical therapy
• Radiculopathy present - positive tension signs or sensory/motor neurologic deficits present
• Recent MRI confirming single-level lumbar disc herniation corresponding to clinical evaluation

You may not qualify if…

• Concomitant spinal stenosis, segmental instability, or spondylolisthesis
• Previous surgery at the affected level or recurrent herniation
• Underlying disease that may affect response to steroids - immunocompromise, use of chronic steroids or immunosuppression
• Pregnancy - qualitative human chorionic gonadotropin (hCG) testing will be performed prior to enrollment
• Diagnosis of or symptoms concerning for cauda equina syndrome

Where it is running

• Missouri Orthopaedic Institute — Columbia, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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