Pediatric ACEs Screening and Resiliency Study
Completed · Not applicable
Conditions studied: Fibrinogen Abnormality, Telomere Length, Mean Leukocyte, Atopic, Acute Infection, Inflammatory Response, Self-regulation
In brief
Stressful and traumatic experiences in childhood (Adverse Childhood Events, or ACEs) have been associated with poor health outcomes that extend into adulthood. When stress is sustained or severe in the absence of an adequate buffer, the stress response can become dysregulated--a state referred to as toxic stress. Some professional organizations have advocated for ACEs screening to be part of routine medical care. To date, however, no ACEs screening tool has been validated for use with children. Intervening early at critical points in the life course has the potential to allow a child to avoid the negative consequences of these adverse events. The proposed study has three overarching aims: (1) Examine the relationship between ACEs, stress biomarkers, and symptoms in children and caregivers over time; (2) Validate an ACEs screening in a pediatric health care setting; and (3) Test whether providing primary care-based preventive interventions for children with or at risk for toxic stress can lead to detectable changes in biomarkers, behavior, or health outcomes for children and/or caregivers.
Key facts
- Study ID
- NCT04182906
- Run by
- UCSF Benioff Children's Hospital Oakland
- People needed
- 555
- Starts
- 2017-03-17
- Expected to finish
- 2019-12-23
- Last updated by the study team
- 2021-04-21
Who can join
Age: 0 and older, up to 11. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- English and Spanish-speaking
- Patients receiving a well visit at Primary Care.
- Parents/primary caregivers of the children above, ages 18 and over, who are also legal guardians capable of consent.
You may not qualify if…
- Children who are dependents of the court
- Caregiver active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with full participation in the study
- Child or caregiver serious illness (mental or physical; requiring systemic treatment and/or hospitalization) or significant developmental disability that would interfere with full participation in the study
- Inability or unwillingness of subject or legal guardian/representative to give written informed consent.
Where it is running
- UCSF Benioff Children's Hospital Oakland — Oakland, California, United States
Full record on ClinicalTrials.gov
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