Long Term Efficacy of Neuronavigation Guided rTMS in Alleviating Gulf War Illness Related Headaches and Pain Symptoms
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Gulf War Syndrome, Gulf War Illness, Headache, Muscle Pain, Joint Pain
In brief
This study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rTMS) in relieving Gulf War Illness related headaches and pain.
Key facts
- Study ID
- NCT04182659
- Run by
- Veterans Medical Research Foundation
- People needed
- 150
- Starts
- 2019-10-01
- Expected to finish
- 2023-09-30
- Last updated by the study team
- 2023-08-09
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female under 65 years of age who served in the military for at least 30 consecutive days between August 1, 1990, and July 31, 1991 in the Persian Gulf War region
- Center for Disease Control (CDC) Criteria for Gulf War Illness (GWI)
- Kansas Criteria for GWI
- International Headache Society Criteria for Migraine Headache without aura Average Headache Exacerbation Intensity >3 on 0-10 a Numerical Pain Rating scale (NPS)
- Average Overall Daily Muscle Pain Intensity >3 on 0-10 a NPS
- Average Overall Daily Extremities Joint Pain Intensity >3 on 0-10 a NPS
- Headache Exacerbation/attack 3 times per week with the average intensity >3 on a 0-10 NPS, lasting > 4 hours in the past three months
- Hamilton Rating Scale of Depression (HRSD) <14 based on the sum of scores for the first 17 items
You may not qualify if…
- Pregnancy
- History of pacemaker implant
- Any ferromagnetic (e.g. bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI
- History of dementia, major psychiatric diseases, or life-threatening diseases
- Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy
- History of seizure
- Pending litigation
- Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy
- Lack of ability to understand the experimental protocol and to adequately communicate in English
- History of Traumatic Brain injury
- Chronic Tension or Cluster Headache
- Ongoing Cognitive Rehabilitation or Treatment of PTSD
Where it is running
- VA Palo Alto — Palo Alto, California, United States (enrolling)
- VA San Diego Healthcare System — San Diego, California, United States (enrolling)
- VA Atlanta — Decatur, Georgia, United States (enrolling)
Full record on ClinicalTrials.gov
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