A Study to Evaluate the Safety and Efficacy of Polatuzumab Vedotin in Combination With Rituximab, Gemcitabine and Oxaliplatin Compared to Rituximab, Gemcitabine and Oxaliplatin Alone in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Completed · Phase 3

Conditions studied: Diffuse Large B-Cell Lymphoma

In brief

This study is a multicenter, open-label study of polatuzumab vedotin administered by intravenous (IV) infusion in combination with rituximab, gemcitabine and oxaliplatin (R-GemOx) in participants with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The study comprises of two stages: a safety run-in stage and a randomized controlled trial (RCT).

Key facts

Study ID

NCT04182204

Run by

Hoffmann-La Roche

People needed

270

Starts

2020-02-07

Expected to finish

2024-11-29

Last updated by the study team

2025-12-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically-confirmed diffuse large B-cell lymphoma, not otherwise specified (NOS) or history of transformation of indolent disease to DLBCL
• Relapsed disease (disease that has recurred following a response that lasted ≥ 6 months from completion of the last line of therapy) or refractory disease (disease that did not respond to or that progressed during therapy or progressed within 6 months (< 6 months) of prior therapy)
• At least one (≥ 1) line of prior systemic therapy:
• Patients may have undergone autologous hematopoietic stem cell transplantation (HSCT) prior to recruitment; In such cases, salvage chemotherapy (e.g., rituximab, dexamethasone, cytarabine, and cisplatin [R-DHAP] and rituximab, ifosfamide, carboplatin, and etoposide phosphate [R-ICE]) will be counted as one line of therapy and conditioning chemotherapy (e.g., BEAM) followed by consolidative autologous HSCT will be counted as one line of therapy
• Patients may have undergone allogeneic HSCT prior to recruitment, so long as they are off all immunosuppressive therapy and have no active GVHD; In such cases, salvage chemotherapy (e.g., R-DHAP and R-ICE) will be counted as one line of therapy and conditioning chemotherapy (e.g., carmustine, etoposide, cytarabine, and melphalan [BEAM]) followed by allogeneic HSCT will be counted as a separate line of therapy
• Participants may have undergone CAR T-cell therapy prior to recruitment. In such cases, cell collection, conditioning chemotherapy, and infusion will be counted as one line of therapy.
• Local therapies (e.g., radiotherapy) will not be considered as lines of treatment
• For participants with a history of the transformation of indolent disease to DLBCL, it is preferred that participants have received at least one treatment for the transformed lymphoma. However, if there are cases where the participants have received an anthracycline-containing chemotherapy regimen (such as R-CHOP) for the indolent lymphoma only, then these participants can be considered as eligible.
• At least one bi-dimensionally measurable lesion, defined as > 1.5 cm in its longest dimension as measured by CT or MRI
• Eastern Cooperative Oncology Group (ECOG) performance status of 0,1 or 2
• Adequate hematological function
• For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception, and agreement to refrain from donating eggs
• For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and agreement to refrain from donating sperm,

You may not qualify if…

• History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies (or recombinant antibody-related fusion proteins) or known sensitivity or allergy to murine products
• Contraindication to rituximab, gemcitabine or oxaliplatin
• Peripheral neuropathy assessed to be > Grade 1 according to NCI CTCAE v5.0
• Prior use of polatuzumab vedotin or a gemcitabine plus platinum-based agent combination, recent participation in a clinical trial, and/or treatment with radiotherapy, chemotherapy, immunotherapy, immunosuppressive therapy within 2 weeks
• Planned autologous or allogenic stem cell transplantation or CAR T-cell therapy at time of recruitment
• Primary or secondary central nervous system (CNS) lymphoma
• Richter's transformation or prior CLL
• Abnormal laboratory values or health conditions, as assessed by the investigator, any known conditions preventing adherence to protocol or active bacterial, viral, fungal, mycobacterial, parasitic, or other infection
• Vaccination with a live vaccine within 4 weeks prior to treatment
• Recent major surgery (within 6 weeks before the start of Cycle 1 Day 1) other than for diagnosis
• Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the patient at high risk from treatment complications
• Pregnant or breastfeeding, or intending to become pregnant during the study or within 12 months after the last dose of study drug
• Women of childbearing potential must have a negative serum pregnancy test result within 7 days prior to initiation of study drug

Where it is running

• Memorial Cancer Institute at Memorial West — Pembroke Pines, Florida, United States
• IHA Hematology Oncology Consultants - Ann Arbor — Ann Arbor, Michigan, United States
• MSKCC at Basking Ridge — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Cancer Center at Bergen — Montvale, New Jersey, United States
• Memorial Sloan-Kettering Cancer Center — New York, New York, United States
• Memorial Sloan Kettering Nassau — Uniondale, New York, United States
• Hospital Sao Rafael - HSR — Salvador, Estado de Bahia, Brazil
• Liga Norte Riograndense Contra O Câncer — Natal, Rio Grande do Norte, Brazil
• Hospital das Clinicas - UFRGS — Porto Alegre, Rio Grande do Sul, Brazil
• Hospital das Clinicas - FMUSP — São Paulo, São Paulo, Brazil
• London Health Sciences Centre — London, Ontario, Canada
• Niagara Health Systems - St. Catherines General Site — St. Catharines, Ontario, Canada
• Centre hospitalier regional de Trois-Rivieres — Trois-Rivières, Quebec, Canada
• Hu Nan Provincial Cancer Hospital — Changsha, China
• West China Hospital - Sichuan University — Chengdu, China
• Cancer Center, Sun Yat-sen University of Medical Sciences — Guangzhou, China
• The 1st Affiliated Hospital of Nanchang Unversity — Nanchang, China
• Guangxi Cancer Hospital of Guangxi Medical University — Nanning, China
• Institute of Hematology and Hospital of Blood Disease — Tianjin, China
• Union Hospital Tongji Medical College Huazhong University of Science and Technology — Wuhan, China
• First Affiliated Hospital of Medical College of Xi'an Jiaotong University — Xi'an, China
• Oulu University Hospital — Oulu, Finland
• Tampere University Hospital — Tampere, Finland
• Hopital Henri Mondor — Créteil, France
• Cancer Specialists — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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