Nasal Inhalation of Isopropyl Alcohol for the Treatment of Nausea in Patients With Cancer

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Malignant Neoplasm

In brief

The goal of this research study is to understand the effect of inhalation approaches in reducing nausea in cancer patients.

Key facts

Study ID

NCT04181463

Run by

M.D. Anderson Cancer Center

People needed

112

Starts

2026-11-05

Expected to finish

2028-12-30

Last updated by the study team

2026-05-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Rate current severity of acute/chronic nausea >= 4 on NRS (Numeric Rating Scale)
• Diagnosis of cancer
• Able to read/write in English
• Referred to supportive care service as an inpatient or outpatient
• Rate anxiety as =< 4 on ESAS-FS (Edmonton Symptom Assessment Scale-Financial Distress and Spiritual Pain)
• Participants must agree to inhale isopropyl alcohol

You may not qualify if…

• Received anti-emetics in the last 30 minutes
• Received medical procedures (e.g. blood draws) which required exposure of isopropyl alcohol in the last 30 minutes
• Inability to inhale through nares (including recent upper respiratory infection)
• Known allergy to isopropyl alcohol
• Delirium (i.e., score >= 7 on the Memorial Delirium Assessment Scale [MDAS])
• Have never been on anti-emetics during the course of the treatment here (anti-emetic naive)

Where it is running

• M D Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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