Skin Tape Transcriptome Methods in Children

Completed

Conditions studied: Atopic Dermatitis

In brief

This pilot study will evaluate new methods for the collection, storage, shipment, and RNA extraction of skin tape specimens from children with atopic dermatitis (AD) that will facilitate the multi-center SunBeam Birth Cohort study. Additionally, this pilot study will test new methods for the generation of whole transcriptome sequencing data from skin tape RNA and whether these data reflect the transcriptional state of the skin in health and disease.

Key facts

Study ID

NCT04180644

Run by

National Jewish Health

People needed

20

Starts

2020-01-10

Expected to finish

2020-02-05

Last updated by the study team

2020-04-13

Who can join

Age: 4 and older, up to 12. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to provide informed consent/assent.
• Male or female, 4-12 years of age (prepuberty) inclusive at the time of consenting
• Participant must be either:
• Active atopic dermatitis with two areas of non-lesional AD within 5 cm of the measured lesional area within the same region.
• OR
• .No personal history or current manifestations of AD, food allergy, asthma, allergic rhinitis, and no positive prick or blood testing for allergen (based on self-report); and no evidence of dry skin or other skin condition

You may not qualify if…

• Unable to provide consent or comply with the protocol
• Presence of any skin condition that might compromise the stratum corneum barrier in infants and young children (e.g., ichthyosis, psoriasis, extensive seborrheic dermatitis, scabies)
• History of any skin reaction to tape, or adhesives
• Past or current medical problems or findings from physical examination or laboratory testing that are not listed above, which in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.
• Use of any topical product (e.g., emollient, topical corticosteroids, topical immunomodulatory agents, topical antibiotics) on the area(s) to be tested within 24 hours before the study visit.

Where it is running

• National Jewish Health and University of Colorado Denver — Denver, Colorado, United States

Full record on ClinicalTrials.gov

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