Coordinating Opioid Use Treatment Through Medical Management With Infection Treatment (Project COMMIT)
Completed · Not applicable
Conditions studied: Opioid-use Disorder
In brief
This study seeks to test a new model of care (ID/LAB) in which opioid use disorder (OUD) is managed by infectious disease (ID) specialists and hospitalists concurrent with management of the OUD-related infections, using long-acting injectable buprenorphine (LAB), followed by referral as soon as possible after hospital discharge to community resources for long term treatment of OUD.
Key facts
- Study ID
- NCT04180020
- Run by
- Yale University
- People needed
- 171
- Starts
- 2020-08-18
- Expected to finish
- 2024-04-25
- Last updated by the study team
- 2026-07-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults able to provide written informed consent in English or Spanish;
- Current hospitalization with a suspected or known bacterial or viral (HIV/HCV/HBV) infection including but not limited to bacteremia, Candidal fungemia, osteomyelitis, endophthalmitis, septic thrombophlebitis, infected pseudoaneurysm, endocarditis, skin/soft tissue infection (SSTI), or septic arthritis;
- Current moderate-to-severe OUD (DSM-5);
- Willing to accept assignment to either ID/LAB or TAU, and to participate in research follow-up visits.
You may not qualify if…
- Severe medical or psychiatric disability making participation unsafe (e.g. imminent suicide risk);
- Pregnancy, planning conception, or breast-feeding for female participants;
- Allergy, hypersensitivity or medical contraindication to buprenorphine;
- Moderate-severe liver impairment in the judgment of the study investigator;
- Preexisting enrollment on methadone or buprenorphine (SL-B) maintenance AND intending to remain on methadone or buprenorphine maintenance upon discharge (patients already under effective treatment for OUD do not represent the target population of untreated OUD patients entering hospitals, nor would we want to disrupt established effective treatment).
- Inability or unwillingness of subject to give informed consent.
Where it is running
- Yale New Haven Hospital — New Haven, Connecticut, United States
- Penn State Health Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
- Prisma Health — Greenville, South Carolina, United States
Full record on ClinicalTrials.gov
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