Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults
Recruiting now · Not applicable
Conditions studied: Acute Lymphoblastic Leukemia
In brief
After consolidation therapy adult patients (≥18 yr) with Ph-negative ALL will be treated with continuation chemotherapy or allogeneic hematopoietic stem cell transplantation (alloHSCT) according to both measurable residual disease (MRD) and results of genetic study performed at baseline.
Key facts
- Study ID
- NCT04179929
- Run by
- PETHEMA Foundation
- People needed
- 300
- Starts
- 2019-11-25
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2022-02-18
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients 18-60 yr with de novo Ph-neg ALL
- Eastern Cooperative Oncology Group (ECOG) 0-2 (or >2 if due to ALL)
- Informed consent
You may not qualify if…
- Mature B-ALL, Ph+ ALL or blast crisis of chronic myeloid leukemia (CML), ALL of ambiguous lineage
- ECOG >2 not due to ALL
- Impaired cardiac, respiratory, hepatic or renal function not due to ALL
- Pregnancy
- HIV positivity
- Severe psychiatric disease
- Negative to sign informed consent.
Where it is running
- H. Central de Asturias — Oviedo, Spain (enrolling)
- ICO-Dr.Josep Trueta — Girona, Spain (enrolling)
- H. Arnau De Vilanova — Lleida, Spain (enrolling)
- H. Regional de Málaga — Málaga, Spain (enrolling)
- Complejo Hospitalario Navarra — Pamplona, Spain (enrolling)
- H. la Fe — Valencia, Spain (enrolling)
- Complejo Hospitalario Ciudad de Jaén — Jaén, Spain (enrolling)
- H Dr. Negrín — Las Palmas de Gran Canaria, Spain (enrolling)
- H. Madrid-Norte Sanchinarro — Madrid, Spain (enrolling)
- H. Clínico Univ. Virgen de la Victoria — Málaga, Spain (enrolling)
- H. Son Espases — Palma de Mallorca, Spain (enrolling)
- Hospital Nuestra Señora de Sonsoles — Ávila, Spain (enrolling)
- Complejo Hosp. Univ. Santiago de Compostela — Santiago de Compostela, Spain (enrolling)
- H. Virgen del Rocío — Seville, Spain (enrolling)
- Hu Basurto — Bilbao, Spain (enrolling)
- H. General Univ. de Alicante — Alicante, Spain (enrolling)
- H. Clínic de Barcelona — Barcelona, Spain (enrolling)
- H. Jerez de la Frontera — Jerez de la Frontera, Spain (enrolling)
- Ico-Hugtip — Badalona, Barcelona, Spain (enrolling)
- H Puerta de Hierro — Madrid, Spain (enrolling)
- H. Sant Pau — Barcelona, Spain (enrolling)
- H. Ramón y Cajal — Madrid, Spain (enrolling)
- H. Vall d'Hebron — Barcelona, Spain (enrolling)
- H Basurto — Bilbao, Spain
- ICO-Duran i Reynals — Bellvitge, Spain
Full record on ClinicalTrials.gov
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