Anti-inflammatory Actions of Osteopathic Manipulative Treatment
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Inflammation
In brief
This study evaluates the hypothesis that osteopathic manipulative treatment (OMT) and non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) elicit anti-inflammatory actions through activation of the parasympathetic nervous system. In a cross-over design, research participants will be subjected to various combinations of OMT, taVNS, or sham interventions during four study sessions, that are at least one month apart. During each study session research participants will undergo OMT and/or taVNS for 3 consecutive days. Blood pressure and electrocardiogram (ECG) will be recorded on all three study days to assess parasympathetic nervous system function. On the 3rd study day a blood sample will be taken to assess the effects of OMT and/or taVNS on inflammation.
Key facts
- Study ID
- NCT04177264
- Run by
- Burrell College of Health Sciences
- People needed
- 36
- Starts
- 2020-01-06
- Expected to finish
- 2023-08-01
- Last updated by the study team
- 2023-02-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age of 18 year or above.
You may not qualify if…
- Age under 18 years
- Pregnancy
- Any findings on the osteopathic screening/evaluation that would hinder the effectiveness - of the occipito-atlantal decompression or splenic lymphatic pump technique
- Any medication that interferes with the autonomic nervous system function or the immune system (e.g., beta-blockers, steroids, TNF-α inhibitors)
- Any medical condition that affects the autonomic nervous system or the immune system (e.g., splenomegaly, Epstein-Barr infection within the last 6 months, autonomic neuropathy, pure autonomic failure, rheumatic or autoimmune diseases, acquired autoimmune deficiency syndrome)
- Any chronic diseases, such as diabetes and hypertension
- Current drug or alcohol abuse.
Where it is running
- Burrell College of Osteopathic Medicine — Las Cruces, New Mexico, United States (enrolling)
Full record on ClinicalTrials.gov
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