Exploring Motor Learning in Acute Stroke Through Robotics

Recruiting now · Not applicable

Conditions studied: Stroke, Acute

In brief

The acute phase of stroke is characterized by an enhancement of neural plasticity which supports rapid motor recovery. It is unclear whether acute stroke patients can acquire new motor skills with their affected upper limb. The aims of this research program are: 1. To test the capacity of acute stroke patients (\< 21 days) to learn and retain a complex unimanual motor skill. 2. To explore whether acute stroke to different brain regions (quantified with brain MRI) induces specific deficits in motor skill learning. 3. To compare acute stroke patients with healthy individuals and with chronic stroke patients.

Key facts

Study ID

NCT04171856

Run by

University Hospital of Mont-Godinne

People needed

245

Starts

2020-01-01

Expected to finish

2040-07-01

Last updated by the study team

2025-04-03

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• acute stroke (> 21 days)
• aged 18-90 years
• with a stroke lesion on brain imaging

You may not qualify if…

• " classical " contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophoby, etc ...)
• difficulty in understanding or executing commands
• drug/alcohol abuse
• severe aphasia / cognitive deficits interfering with study
• inability to voluntarily move the affected arm (i.e. complete paralysis of the arm)
• multiple strokes / dementia / psychiatric condition
• PATIENTS WITH TRANSIENT GLOBAL AMNESIA:
• Clinical diagnosis, criteria of Hodge \& Warlow (1990):
• Anterograde amnesia observed by a witness
• No alteration of consciousness or loss of identity
• Cognitive dysfunction limited to amnesia
• Lack of focused neurological deficit or argument for a comitiality
• Absence of head trauma
• Symptom resolution within 24 hours
• Possible existence of vegetative symptoms
• Inclusion criteria:
• Transient global amnesia
• 8-90 years old
• Be able to perform 3 consecutive sessions on a rehabilitation robot
• Exclusion criteria:
• Severe aphasia / cognitive deficits interfering with study
• Psychiatric disorders
• Alcohol / drug addiction
• Exclusion criteria related to MRI
• HEALTHY INDIVIDUALS:

Where it is running

• CHU UCL Namur — Yvoir, Namur, Belgium (enrolling)
• University Hospital CHU Dinant Godinne UCL — Yvoir, Belgium

Full record on ClinicalTrials.gov

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