Radiofrequency Ablation of Atrial Fibrillation Under Apnea

Completed · Not applicable

Conditions studied: Atrial Fibrillation

In brief

This study seeks to assess the effect of apnea (breath hold) during atrial fibrillation (AF) ablation by having all ablations performed under apnea. By prospectively studying the effects of apnea on AF ablation, the investigators wish to demonstrate its feasibility, safety and impact on patient outcomes. This is a prospective study that includes both an apnea arm and a control arm. The subjects who consent to the apnea arm will undergo an atrial fibrillation ablation with periods of apnea. The subjects who consent to the control arm will agree to have their data from their standard of care atrial fibrillation be collected for comparison.

Key facts

Study ID

NCT04170894

Run by

Weill Medical College of Cornell University

People needed

128

Starts

2020-10-08

Expected to finish

2023-08-30

Last updated by the study team

2025-08-03

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 - 80 years old.
• Symptomatic paroxysmal atrial fibrillation.

You may not qualify if…

• Patients with persistent or permanent atrial fibrillation or prior atrial fibrillation ablation.
• Significant chronic obstructive pulmonary disease (such as those requiring home oxygen).
• Severe pulmonary hypertension.
• Other intrinsic lung pathology such as interstitial lung disease.
• Severe systolic dysfunction defined as left ventricular ejection fraction < 30%.

Where it is running

• Southside Hospital — Bay Shore, New York, United States
• North Shore Hospital — Manhasset, New York, United States
• New York Presbyterian Hospital - Weill Cornell Medicine — New York, New York, United States
• Lenox Hill Hospital — New York, New York, United States
• Long Island Jewish Medical Center — Queens, New York, United States
• Houston Methodist Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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