Deep Vein Thrombosis Prophylaxis Adherence: Enoxaparin vs Rivaroxaban

Status unconfirmed · Phase 4

Conditions studied: Deep Vein Thrombosis, Venous Thromboembolism

In brief

The objective of this study is to compare oral rivaroxaban with injectable enoxaparin in orthopaedic trauma patients to determine if orally administered rivaroxaban once daily carries greater compliance and overall satisfaction than enoxaparin self-administered by subcutaneous injection once daily.

Key facts

Study ID

NCT04169269

Run by

Florida Orthopaedic Institute

People needed

128

Starts

2020-01-13

Expected to finish

2021-12-01

Last updated by the study team

2020-01-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Orthopaedic trauma patients deemed by the attending, treating surgeon to require an extended duration of venous thromboembolism chemoprophylaxis beyond that provided as an inpatient.
• Patients being discharged directly to home.

You may not qualify if…

• • Patients being discharged to a rehabilitation center or a skilled nursing facility.
• A contraindication to anticoagulation such as traumatic or other hemorrhage, as determined by the treating surgeon and/or consulting services.
• Ongoing venous thromboembolism treatment or extended prophylaxis (i.e. past history of multiple deep vein thrombosis/pulmonary embolism) for current or recent deep vein thrombosis, pulmonary embolism or other coagulopathic disorder
• Chronic anticoagulation for atrial fibrillation or other medical disorder requiring chronic anticoagulation therapy.
• Perceived low-risk patients requiring only aspirin or no pharmacological venous thromboembolism prophylaxis.
• Pregnant, prisoner, under 18 years old, or do not speak English

Where it is running

• Florida Orthopaedic Institute — Tampa, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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