Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

Recruiting now · Not applicable

Conditions studied: Appendicitis

In brief

The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.

Key facts

Study ID

NCT04168866

Run by

Yale University

People needed

180

Starts

2020-03-11

Expected to finish

2029-12-31

Last updated by the study team

2025-08-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Complicated appendicitis with presumed perforation on (computer tomography) CT scan AND phlegmon or abscess greater than 2 centimeter (cm).

You may not qualify if…

• Antibiotic therapy greater than 24 hours prior to considering for enrollment.
• Attempted drainage before randomization
• Pregnancy
• Antibiotic allergy requiring the use of something other than a beta-lactam or quinolone based therapy.
• Previous major intra-abdominal surgery by laparotomy
• Hospitalization within 2 weeks of randomization
• Presence of septic shock on admission.
• Mechanical ventilation
• Acute renal failure requiring dialysis

Where it is running

• Yale New Haven Hospital — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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