Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Alpha 1-Antitrypsin Deficiency

In brief

This study will evaluate the efficacy, safety and pharmacokinetics (PK) of VX-814 in PiZZ subjects.

Key facts

Study ID

NCT04167345

Run by

Vertex Pharmaceuticals Incorporated

People needed

48

Starts

2020-01-13

Expected to finish

2020-11-14

Last updated by the study team

2022-02-02

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of California Davis Medical Center — Sacramento, California, United States
• National Jewish Health — Denver, Colorado, United States
• University of Florida, Shands Hospital — Gainesville, Florida, United States
• University of Miami Miller School of Medicine — Miami, Florida, United States
• Central Florida Pulmonary Group, PA — Orlando, Florida, United States
• The University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Blessing Corporate Services, Inc., dba Blessing Health System — Hannibal, Missouri, United States
• Columbia University Medical Center — New York, New York, United States
• University of North Carolina Medical Center — Chapel Hill, North Carolina, United States
• Wake Forest University Baptist Medical Center — Winston-Salem, North Carolina, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Temple University Hospital — Philadelphia, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Renovatio Clinical — Houston, Texas, United States
• The University of Texas Health Science Center at Tyler — Tyler, Texas, United States
• University of Utah Health — Salt Lake City, Utah, United States
• Inova Fairfax Medical Campus — Falls Church, Virginia, United States
• Queen Elizabeth II Health Sciences Center — Halifax, Canada
• Inspiration Research Ltd — Toronto, Canada
• University Hospital RWTH Aachen — Aachen, Germany

Full record on ClinicalTrials.gov

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