Eliminating the Need for Pancreas Biopsy Using Peripheral Blood Cell-free DNA
Completed
Conditions studied: Transplant;Failure,Kidney, Transplant; Failure, Pancreas, Rejection Acute Renal, Rejection Acute Pancreas
In brief
Donor-derived cell-free DNA (dd-cfDNA) has shown promise as an early marker for cellular injury caused by rejection. dd-cfDNA changes may also indicate other injuries that lead to progressive decline in transplant organ function associated with, in the case of kidney transplantation, the presence of interstitial fibrosis (IF) and tubular atrophy (TA) seen in biopsy specimens. Here, we will study the utility of dd-cfDNA to predict rejection in pancreas and pancreas-kidney recipients.
Key facts
- Study ID
- NCT04166149
- Run by
- University of Maryland, Baltimore
- People needed
- 140
- Starts
- 2019-09-01
- Expected to finish
- 2024-09-06
- Last updated by the study team
- 2024-11-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult recipients (Age > 18 years )
- All genders and all racial and ethnic groups
- Pancreas transplant alone (PTA)
- Simultaneous kidney-pancreas transplantation (SPK)
- Pancreas-after-kidney (PAK) 6. Simultaneous pancreas and living donor kidney (SPLK)
- Primary or re-transplants 8. Ability to come for follow-up and undergo biopsy (Performed in accordance to SOC) 9. Provided consent
You may not qualify if…
- Pediatric recipients (Age < 18 years)
- Pregnant women
- Patients undergoing multi-organ transplants not otherwise specified (e.g., pancreas-liver, multi-visceral, or pancreas-heart)
- Patients receiving donor kidney from an identical twin, as part of an SPLK (see above)
- Did not provide consent
Where it is running
- Georgetown University — Washington D.C., District of Columbia, United States
- University of Maryland — Baltimore, Maryland, United States
- UW Health University Hospital — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.