Study to Evaluate Safety and Daytime Sedation in Subjects With Parkinson's Disease With Neuropsychiatric Symptoms Treated With Pimavanserin or Low-Dose Quetiapine

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Parkinson's Disease

In brief

This is a pilot study to explore the effects of pimavanserin and low-dose quetiapine in subjects with Parkinson's disease with neuropsychiatric symptoms.

Key facts

Study ID

NCT04164758

Run by

ACADIA Pharmaceuticals Inc.

People needed

11

Starts

2019-10-23

Expected to finish

2020-09-25

Last updated by the study team

2021-10-14

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female subjects 50 to 85 years of age, inclusive
• Able to understand the protocol requirements and provide written informed consent
• Able to complete questions on a handheld device / tablet, is willing to wear an actigraph and can be reliably rated on assessment scales
• Able to designate an 'informant' (relative, housemate, friend) who can provide information about the subject's well being and attend clinic visits with the subject
• Is able to swallow the test capsule without difficulty during the Screening visit
• Has a Mini-Mental State Examination (MMSE) score ≥19
• Has a diagnosis of idiopathic Parkinson's disease, without any other known or suspected cause of parkinsonism. Initial diagnosis of PD must have been made more than 1 year prior to Screening.
• Has non-motor neuropsychiatric symptoms severe enough to warrant treatment with an antipsychotic agent based on investigator judgement and CGI-S score
• If the subject is on anti-Parkinsonian medication, they must be on a stable regimen for 1 month prior to Baseline and not planning (at the time of the Baseline visit) to make a major change in dose(s)
• If the subject is female, she must not be pregnant or breastfeeding. She must also be of non-childbearing potential or must agree to use a clinically acceptable method of contraception or be abstinent for at least 1 month prior to the Baseline visit, during the study, and 41 days following completion of double-blind treatment.

You may not qualify if…

• Has atypical parkinsonism or secondary parkinsonism variants such as tardive or medication induced parkinsonism
• Is in hospice, is receiving end-of-life palliative care, or is bedridden or confined to a wheelchair
• Has neuropsychiatric symptoms that are primarily attributable to current delirium or substance abuse
• Has current evidence of an unstable neurological, cardiovascular, respiratory, gastrointestinal, renal, hepatic, hematologic, or other medical or psychiatric disorder, including cancer or malignancies that, in the judgment of the Investigator, would jeopardize the safe participation of the subject in the study or significantly interfere with the conduct or interpretation of the study
• Has a known personal or family history of long QT syndrome or family history of sudden cardiac death
• Has orthostatic hypotension as judged by the investigator and medical monitor
• Is judged by the Investigator or the Medical Monitor to be inappropriate for the study for any reason, including if the subject is judged to be a danger to self or others
• Additional inclusion/exclusion criteria apply. Patients will be evaluated at screening to ensure that all criteria for study participation are met. Patients may be excluded from the study based on these assessments (and specifically, if it is determined that their baseline health and condition do not meet all pre-specified entry criteria).

Where it is running

• Movement Disorders Center of Arizona — Scottsdale, Arizona, United States
• Tucson Neuroscience Research — Tucson, Arizona, United States
• Sutter Institute for Medical Research — Sacramento, California, United States
• Galiz Research — Hialeah, Florida, United States
• Charter Research, LLC — Lady Lake, Florida, United States
• Premier Clinical Research Institute, Inc. — Miami, Florida, United States
• Infinity Clinical Research, LLC — Sunrise, Florida, United States
• Charter Research, LLC — Winter Park, Florida, United States
• Meridian Clinical Research — Savannah, Georgia, United States
• Hawaii Pacific Neuroscience, LLC. — Honolulu, Hawaii, United States
• University of lowa Hospital and Clinics — Iowa City, Iowa, United States
• SRI International — Plymouth, Michigan, United States
• Bio Behavioral Health — Toms River, New Jersey, United States
• M3 Wake Research, Inc. — Raleigh, North Carolina, United States
• Dayton Center for Neurological Disorders — Centerville, Ohio, United States
• Prisma Health-Upstate — Greenville, South Carolina, United States

Full record on ClinicalTrials.gov

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