A Longitudinal Study of Inflammatory Pathways in Depression
Completed
Conditions studied: Major Depressive Disorder, Suicide, Attempted
In brief
Suicide accounts for at least 1 million deaths globally each year. This is likely a significant underestimate, because suicide is under-reported in many countries. In the US, over 42,000 people die from suicide annually. Despite increased focus on identification and treatment, the rate of suicide has increased steadily over the past 15 years. Our project aims both to improve our understanding of factors that increase the risk for suicide by comparing blood biomarkers associated with inflammation in patients with depression without suicidal behavior and patients with depression and suicidal behavior. The 160 individuals in this study will be followed with psychiatric assessments and blood samples at repeated time points over one year.
Key facts
- Study ID
- NCT04159207
- Run by
- Van Andel Research Institute
- People needed
- 130
- Starts
- 2019-10-01
- Expected to finish
- 2023-08-30
- Last updated by the study team
- 2025-04-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men and women ages 18 years and older will be included in the study.
- 80 who are diagnosed with MDD by SCID but do not endorse current or past suicidal behaviors.
- 80 who are diagnosed with MDD by SCID and endorse current suicidal behavior as defined by C-SSRS (preparatory acts, aborted or interrupted attempts, as well as completed attempts).
- English speaking.
- Willing and able to take part of the different steps in the study, including follow-up interviews and blood draws.
You may not qualify if…
- Vulnerable populations (e.g. incarcerated individuals).
- Subjects with dementia or otherwise cognitively impaired subjects with difficulty understanding the study procedures.
- Patients with a primary psychiatric diagnosis other than MDD.
- Patients with an active somatic disorder primarily involving the immune system (autoimmune diseases such as Crohns disease, multiple sclerosis, or rheumatoid arthritis; or hematological diseases such as lymphoma or leukemia).
- Patients on chronic and systemic immunomodulatory treatment. Examples are patients with a liver- or kidney transplant or medications used for disorders involving the immune system, as mentioned above. Examples of immunomodulatory treatments are cyclosporin, azathioprine, infliximab, corticosteroid treatment.
- Patients undergoing active treatment for any form of cancer (chemotherapy or immunomodulatory treatments).
Where it is running
- Pine Rest Christian Mental Health Services — Grand Rapids, Michigan, United States
Full record on ClinicalTrials.gov
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