RH Genotype Matched RBC Transfusions

Recruiting now · Phase 1/Phase 2

Conditions studied: Sickle Cells Disease

In brief

To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

Key facts

Study ID

NCT04156893

Run by

Children's Hospital of Philadelphia

People needed

35

Starts

2020-01-30

Expected to finish

2029-10-01

Last updated by the study team

2026-04-27

Who can join

Age: 1 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects age >6 months
• Diagnosis of SCD, all genotypes
• Require a period of chronic red cell transfusion therapy
• Subject/parental/guardian permission (informed consent) and if appropriate, child assent

You may not qualify if…

• Rare RH genotype that would preclude identification of sufficient RBC units
• Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units
• Alloimmunized to D antigen
• Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols
• Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures

Where it is running

• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.