Study to Demonstrate the Efficacy, Safety and Tolerability of an Intravenous Regimen of Secukinumab Compared to Placebo in Subjects With Active axSpA

Completed · Phase 3 · Has a placebo group

Conditions studied: Ankylosing Spondylitis

In brief

The purpose of this global study was to demonstrate the efficacy, safety, and tolerability of an intravenous (i.v.) regimen of secukinumab compared to placebo in participants with active ankylosing spondylitis (AS) or non-radiographic axial spondyloarthritis (nr-axSpA ) at Week 16 despite current or previous non-steroidal anti inflammatory drugs (NSAID), disease-modifying antirheumatic drugs (DMARD) and/or anti Tumor Necrosis Factor (TNF) therapy. In addition, to further support efficacy and safety of an i.v. regimen, data was collected for up to 52 weeks of treatment.

Key facts

Study ID

NCT04156620

Run by

Novartis Pharmaceuticals

People needed

527

Starts

2019-12-11

Expected to finish

2022-12-20

Last updated by the study team

2024-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects eligible for inclusion in this study must meet all of the following criteria:
• Subject must be able to understand and communicate with the investigator, comply with the requirements of the study. and must give written, signed and dated informed consent before any study assessment is performed
• Male and non-pregnant, non-lactating female patients ≥ 18 years of age
• Diagnosis of axSpA according to ASAS criteria
• Inflammatory back pain for at least 6 months
• Onset before 45 years of age
• For subjects with AS: Diagnosis of AS with prior documented radiologic evidence (x-ray or radiologist's report) fulfilling the Modified New York criteria for AS
• For subjects with nr-axSpA:
• X-ray of SIJ negative (centrally read) for AS by Modified NY criteria AND
• Sacroiliitis on MRI (centrally read) with ≥ 1 SpA feature OR HLA-B-27 positive with ≥2 SpA features AND
• Objective signs of inflammation at screening, evident by either MRI with SIJ inflammation (centrally read) AND / OR hsCRP > ULN (as defined by the central lab)
• Active axial SpA assessed by BASDAI ≥4 cm (0-10 cm) at Baseline
• Spinal pain as measured by BASDAI question #2 ≥ 4 cm (0-10 cm) at Baseline
• Total back pain as measured by VAS ≥ 40 mm (0-100 mm) at Baseline
• Subjects should have had inadequate response or failure to respond to at least 2 NSAIDs at an approved dose for a minimum of 4 weeks in total and a minimum of 2 weeks for each NSAID prior to randomization, or less than 4 weeks if therapy had to be withdrawn due to intolerance, toxicity or contraindications
• Subjects who are regularly taking NSAIDs (including COX-1 or COX-2 inhibitors) as part of their AS or nr-axSpA therapy are required to be on a stable dose for at least 2 weeks before randomization
• Subjects who are intolerant or have been inadequate responders to a TNF inhibitor (not more than one) will be allowed to enter into the study (not more than 20% per group). They must have experienced an inadequate response to previous or current treatment at an approved dose for at least 3 months prior to randomization, or have been intolerant to at least one administration of an anti-TNF agent. These subjects will undergo an appropriate wash-out period prior to randomization, if required
• 4 weeks for Enbrel® (etanercept) - with a terminal half-life of 102 ± 30 hours
• 8 weeks for Remicade® (infliximab) - with a terminal half-life of 8.0-9.5 days
• 10 weeks for Humira® (adalimumab) - with a terminal half-life of 10-20 days (average 2 weeks)
• 10 weeks for Simponi® (golimumab) - with a terminal half-life of 11-14 days
• 10 weeks for Cimzia® (certolizumab) - with a terminal half-life of 14 days
• Subjects taking methotrexate (MTX) (≤ 25 mg/week ) or sulfasalazine (≤ 3 g/day) are allowed to continue their medication and must have taken it for at least 3 months and have to be on a stable dose for at least 4 weeks prior to randomization. Subjects on MTX must be on folic acid supplementation before randomization
• Subjects who are on a conventional DMARD other than MTX or sulfasalazine must discontinue the DMARD 4 weeks prior to randomization, except for leflunomide, which must be be discontinued 8 weeks prior to randomization, unless a cholestyramine washout has been performed
• Subjects taking systemic corticosteroids must be on a stable dose of ≤10 mg/day prednisone or equivalent for at least 2 weeks before randomization

You may not qualify if…

• Subjects meeting any of the following criteria are not eligible for inclusion in this study
• Subjects with total ankylosis of the spine
• Chest x-ray or MRI with evidence of ongoing infectious or malignant process obtained within 3 months of screening and evaluated by a qualified physician
• Subjects taking moderate and high potency opioid analgesics (e.g. methadone, hydromorphone, morphine)
• Presence of significant medical problems which at investigator's discretion, will prevent the subject from participating in the study, including but not limited to the following: Subjects with severely reduced kidney function (estimated glomerular filtration rate (eGFR) <29 ml/min/1.73m2), history of renal trauma, glomerulonephritis, or patients with one kidney only, or a serum creatinine level exceeding 1.5 mg/dl (132.6 μmol/L)
• Any therapy by intra-articular injections (e.g. corticosteroid) within 4 weeks before Randomization
• Underlying conditions (including, but not limited to metabolic, hematologic, renal, hepatic, pulmonary, neurologic, endocrine, cardiac, infectious or gastrointestinal) which in the opinion of the investigator significantly immunocompromises the subject and/or places the subject at unacceptable risk for receiving an immunomodulatory therapy
• Any medical or psychiatric condition which, in the Investigator's opinion, would preclude the participant from adhering to the protocol or completing the study per protocol
• Active systemic infections during the last two weeks (exception: common cold) prior to randomization or any infection that reoccurs on a regular basis
• History of ongoing, chronic or recurrent infectious disease or evidence of tuberculosis infection as defined by either a positive purified protein derivative (PPD) skin test (the size of induration will be measured after 48-72 hours, and a positive result is defined as an induration of ≥ 5 mm or according to local practice/guidelines) or a positive QuantiFERON TB-Gold test as indicated in the assessment schedule in Table 8-1. Subjects with a positive test may participate in the study if further work up (according to local practice/guidelines) establishes conclusively that the subject has no evidence of active tuberculosis. If presence of latent tuberculosis is established, then treatment according to local country guidelines must have been initiated
• Past medical history of infection with HIV or hepatitis B prior to randomization or active infection or on treatment for Hepatitis C at randomization
• History of lymphoproliferative disease or any known malignancy, or history of malignancy of any organ system treated or untreated within the past 5 years, regardless of whether there is evidence of local recurrence or metastases (except for skin Bowen's disease, or basal cell carcinoma or actinic keratoses that have been treated with no evidence of recurrence in the past 12 weeks; carcinoma in situ of the cervix or non-invasive malignant colon polyps that have been removed)
• Use or planned use of prohibited concomitant medication (see Section 6.2.2)
• Inability or unwillingness to undergo repeated venipuncture (e.g., because of poor tolerability or lack of access to veins)
• Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test
• History or evidence of ongoing alcohol or drug abuse, within the last six months before randomization
• Screening total WBC count <3,000/μl, or platelets <100,000/μl or neutrophils <1,500/μl or hemoglobin <8.5 g/dl (85 g/L)
• History of clinically significant liver disease or liver injury indicated by abnormal liver function tests, such as SGOT (AST), SGPT (ALT), alkaline phosphatase and serum bilirubin. The investigator should be guided by the following criteria:
• Any single parameter may not exceed 2 x the upper limit of normal (ULN). A single parameter elevated up to and including 2 x ULN should be re-checked once more as soon as possible, and in all cases, at least prior to randomization, to rule-out laboratory error.
• If the total bilirubin concentration is increased above 2 x ULN, total bilirubin should be differentiated into the direct and indirect reacting bilirubin. In any case, serum bilirubin should not exceed the value of 1.6 mg/dL (27 µmol/L)
• Significant medical problems or diseases, including but not limited to the following:
• uncontrolled hypertension (≥160/95 mmHg), congestive heart failure (New York Heart Association status of class III or IV), uncontrolled diabetes, or very poor functional status precluding ability to perform self-care
• Plans for administration of live vaccines during the study period or within 6 weeks prior to randomization
• Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using effective methods of contraception during the entire study or longer if required by locally approved prescribing information (e.g., 20 weeks in EU). Effective contraception methods include:
• Total abstinence (when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception

Where it is running

• Novartis Investigative Site — La Mesa, California, United States
• Novartis Investigative Site — San Leandro, California, United States
• Novartis Investigative Site — Upland, California, United States
• Novartis Investigative Site — Ocoee, Florida, United States
• Novartis Investigative Site — Plantation, Florida, United States
• Novartis Investigative Site — Winter Park, Florida, United States
• Novartis Investigative Site — Bowling Green, Kentucky, United States
• Novartis Investigative Site — Cumberland, Maryland, United States
• Novartis Investigative Site — Grand Blanc, Michigan, United States
• Novartis Investigative Site — Lincoln, Nebraska, United States
• Novartis Investigative Site — Potsdam, New York, United States
• Novartis Investigative Site — Greensboro, North Carolina, United States
• Novartis Investigative Site — Middleburg Heights, Ohio, United States
• Novartis Investigative Site — Portland, Oregon, United States
• Novartis Investigative Site — Duncansville, Pennsylvania, United States
• Novartis Investigative Site — Columbia, South Carolina, United States
• Novartis Investigative Site — Jackson, Tennessee, United States
• Novartis Investigative Site — Memphis, Tennessee, United States
• Novartis Investigative Site — Katy, Texas, United States
• Novartis Investigative Site — Spring, Texas, United States
• Novartis Investigative Site — The Woodlands, Texas, United States
• Novartis Investigative Site — Everett, Washington, United States
• Novartis Investigative Site — Spokane, Washington, United States
• Novartis Investigative Site — Beckley, West Virginia, United States
• Novartis Investigative Site — Irvine, California, United States

Full record on ClinicalTrials.gov

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