Osmotic Agent Use in Middle Cerebral Artery Stroke

Completed

Conditions studied: Ischemic Stroke, MCA Infarction

In brief

This is a retrospective chart review of patients that were admitted with large MCA stroke to the Fairview system hospitals between December 2017-December 2018. Patients ischemic stroke volumes will be measured by taking the area of the infarction and multiplying it by the thickness of each CT or MRI slice, the summation of these volumes is the final volume of the ischemic lesion in cubic centimeters. Patients with stroke volumes greater than 70 cc will be included in the study. Patient midline shift will be measured in millimeters at the level of foramen of Monroe anytime during their initial admission and all patients with a shift greater than 1mm will be included. The midline shift will be documented on the first follow-up brain scan (CT or MRI) at least six hours after the initiation of osmotic therapy. Data will be collected from patient charts including: Age, sex, NIHSS on presentation and discharge, history of diabetes mellitus, hypertension, coronary artery disease, atrial fibrillation, and chronic kidney disease. The type of osmotherapy, along with change in serum sodium or osmolality and dose, will also be documented. In patients that did not receive osmotherapy, midline shift will be documented on the first 24-hour scan and every subsequent scan in 24-hour intervals. Death during a hospital stay will also be recorded. The investigators will use the SAS statistical suite to analyze this data.

Key facts

Study ID

NCT04156490

Run by

University of Minnesota

People needed

100

Starts

2018-02-10

Expected to finish

2019-06-30

Last updated by the study team

2019-11-07

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• MCA stroke greater than 70cc in size.
• Patients with a midline shift > 1 mm
• Age 18-80 years old

You may not qualify if…

• Hemorrhagic conversion (PH2 or higher. )
• Hemicraniectomy within 6 hours from initiation of hypertonic therapy
• Hemicraniectomy with no repeat CT imaging prior to the operation
• Hemicraniectomy emergently without hypertonic therapy

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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