Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit

Status unconfirmed · Phase 4

Conditions studied: Alcohol Withdrawal, Alcohol Withdrawal Delirium

In brief

Our aim is to compare outcomes of patients with benzodiazepine-refractory alcohol withdrawal syndrome who are treated with either a phenobarbital-based or a lorazepam based protocol.

Key facts

Study ID

NCT04156464

Run by

OSF Healthcare System

People needed

142

Starts

2020-07-06

Expected to finish

2022-03-01

Last updated by the study team

2020-10-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients will be eligible for randomization if he/she has met one of the following three conditions:
• has required more than 10 mg of lorazepam within a one hour time period,
• has required more than 30 mg of lorazepam within a four hour time period, or
• requires admission/transfer to the intensive care unit for primarily uncontrolled alcohol withdrawal symptoms

You may not qualify if…

• Patients will be excluded from the study if he/she:
• has a traumatic brain injury or other neurological condition requiring frequent neurological assessment (stroke, intracranial hemorrhage, active seizures on admission)
• has severe hypotension requiring vasopressor support
• is less than 18 years of age
• is actively pregnant
• has an allergy to either of the drugs being studied (phenobarbital or lorazepam)
• is already intubated at the time of randomization

Where it is running

• OSF Saint Francis Medical Center — Peoria, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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