Study of Autologous Peripheral Blood Lymphocytes in the Treatment of Patients With CLL or SLL

Completed · Phase 1

Conditions studied: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

In brief

This is a Phase 1/2, study evaluating IOV-2001 (Adoptive Cell Therapy) composed of autologous PBL (Peripheral Blood Lymphocytes) in patients with CLL/SLL, which has relapsed or is relapsing during treatment with ibrutinib or acalabrutinib.

Key facts

Study ID

NCT04155710

Run by

Iovance Biotherapeutics, Inc.

People needed

7

Starts

2020-02-19

Expected to finish

2024-12-02

Last updated by the study team

2025-12-24

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with CLL or SLL with radiographically measurable disease
• Cohort 2 only: patients with progressed or progressing CLL/SLL on ibrutinib or acalabrutinib with del 17p and/or TP53 mutated
• Cohort 3 only: patients with progressed or progressing CLL/SLL on ibrutinib or acalabrutinib without del 17p and/or TP53 mutated
• Patients must have documented progression or be progressing on ibrutinib or acalabrutinib, as indicated by the presence of known BTK resistance mutation
• Patients must have received at least 1 prior regimen (only for patients without del 17p and/or TP53 mutated) and currently be on ibrutinib or acalabrutinib. For patients on combination therapy as the last line of therapy prior study entry, progression to any of the individual components of the combination therapy, rather than to the combination regimen, is required.
• For Cohort 2: The single prior regimen can be ibrutinib or acalabrutinib (ie, patients are eligible while progressing on their first line of therapy)
• For Cohort 3: Patients must have progressed on at least 1 additional line of therapy in addition to ibrutinib or acalabrutinib
• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 and an estimated life expectancy of ≥ 3 months.
• Patients must have adequate bone marrow function to receive NMA-LD
• Pulmonary function assessed by spirometry demonstrating FEV1 > 50% predicted normal
• Cardiac function demonstrating left ventricular ejection fraction (LVEF) > 45%
• Patients of childbearing potential or their partners of childbearing potential must be willing to practice an approved method of birth control during treatment and for 12 months after receiving the last protocol-related therapy.

You may not qualify if…

• Patients who have received an organ allograft or prior cell transfer therapy within 20 years.
• Patients with known or suspected transformed disease (ie, Richter's Transformation).
• Patients who received treatment with any systemic chemotherapy, immunotherapy, targeted small molecule inhibitors, or other biologic agents within 30 days or 5 half-lives, whichever is shorter, of IOV-2001 infusion with the exception of ibrutinib or acalabrutinib
• Patients with known involvement of central nervous system (CNS) by lymphoma or leukemia
• Patients who are on chronic systemic steroid therapy >5 mg/day prednisone equivalent for any reason
• Patients who have active systemic infections requiring systemic ABX, autoimmune anemia or thrombocytopenia, coagulation disorders, or other active major medical illnesses of the cardiovascular, respiratory, or immune system.
• Patients who are seropositive for any of the following:
• Human immunodeficiency virus (HIV)-1 or HIV-2 antibodies
• Hepatitis B antigen (HbsAg) or anti-hepatitis B core total antibodies (anti-HbcAb), or hepatitis C antibody (HCVAb)
• Patients with active and chronic fungal, bacterial, or viral infection requiring IV treatment
• Patients who require treatment for anti-coagulation with a vitamin K antagonist (warfarin)
• Patients who have received a live or attenuated vaccine within 28 days of beginning the preparative NMA-LD regimen
• Patients who are pregnant or breastfeeding

Where it is running

• Moffitt Cancer Center — Tampa, Florida, United States
• Duke University — Durham, North Carolina, United States
• University of Cincinnati Medical Center — Cincinnati, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• Allegheny Health — Pittsburgh, Pennsylvania, United States
• Baptist Cancer Center — Memphis, Tennessee, United States
• University of Utah, Huntsman Cancer Institute — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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