Pharmacogenetic Testing of Patients With Unwanted Adverse Drug Reactions or Therapy Failure

Recruiting now

Conditions studied: Adverse Drug Reaction, Therapy Failure

In brief

Genetic makeup of a patient influences the efficacy and safety profile of a drug. This study is to summarize individual cases, where Pharmacogenetics (PGx) has been applied during pharmaceutical care. The primary objective is the compilation of case reports, where pharmacogenetic testing is applied to determine the hereditable component of the patient's susceptibility to experience therapy failure and/or adverse drug reactions. The experience with the compiled cases will be basis for the development of a reliable standard of procedure for pharmacogenetic testing in the community pharmacy. The cases will be supplemented with information on additional Parameters reported in the literature to affect efficacy or safety of the respective drug.

Key facts

Study ID

NCT04154553

Run by

University Hospital, Basel, Switzerland

People needed

400

Starts

2019-10-15

Expected to finish

2026-08-01

Last updated by the study team

2025-05-14

Who can join

Age: 2 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• New medication with known PGx association (preemptive)
• Current medication with observation of adverse drug reactions probably linked to drugs with known PGx association (reactive)
• Current medication with observation of therapy failure probably linked to drugs with known PGx association (reactive)
• Current and/or new medication and a family history of adverse drug reactions/therapy failure probably linked to drugs with known PGx association
• Signed informed consent; for patients < 14 years, the legal representative needs to sign the informed consent

You may not qualify if…

• Insufficient German knowledge
• Not able to personally visit to the study pharmacy

Where it is running

• Department of Pharmaceutical Sciences, University Basel — Basel, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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