Exosome Cargo From Preeclampsia Patients
Recruiting now
Conditions studied: Preeclampsia
In brief
Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia. Recent data revealed that exosomes released from the placenta could cause preeclampsia by transporting specific cargo responsible for the pathophysiological changes associated with the systemic disease. By isolating these exosomes from maternal blood and placental tissue in patients diagnosed with preeclampsia and studying their biochemical, cellular and molecular mechanism in an animal model, the investigators hope to elucidate the critical role that exosomal cargo plays in the development of preeclampsia and cardiovascular remodeling. This will be accomplished by obtaining patient samples from volunteers delivering at the Women and Infants Center and taking the samples to the lab for quantification, characterization, and identification of key functional roles through in/ex vivo, in vitro, and profiling studies. The investigators believe this work will be valuable as hope exists to define the functional role exosomes play in the development of preeclampsia that leads to cardiovascular remodeling. Data from this study will shed more light on the functional role of exosomal cargo in normal and pathological pregnancies and point towards novel therapeutic intervention strategies for preeclampsia associated with cardiovascular disease.
Key facts
- Study ID
- NCT04154332
- Run by
- University of Alabama at Birmingham
- People needed
- 64
- Starts
- 2019-12-02
- Expected to finish
- 2031-12-15
- Last updated by the study team
- 2026-07-07
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may not qualify if…
- Preeclampsia patients: Age < 18 years; Any other diagnosis of pregnancy-induced hypertension that isn't preeclampsia with severe features (i.e. gestational hypertension or preeclampsia without severe features).
- Control Patients: Age < 18 years; Any diagnosis of pregnancy-induced hypertension.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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